Structural biology of the macroautophagy machinery  

作　　者：Leon H. CHEW Calvin K. YIP 

机构地区：[1]Department of Biochemistry and Molecular Biology, The University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T1Z3, Canada

出　　处：《Frontiers in Biology》2014年第1期18-34,共17页生物学前沿（英文版）

摘　　要：Macroautophagy is a conserved degradative process mediated through formation of a unique double- membrane structure, the autophagosome. The discovery of autophagy-related （Atg） genes required for autophagosome formation has led to the characterization of approximately 20 genes mediating this process. Recent structural studies of the Atg proteins have provided the molecular basis for their function. Here we summarize the recent progress in elucidating the structural basis for autophagosome formation.Macroautophagy is a conserved degradative process mediated through formation of a unique double- membrane structure, the autophagosome. The discovery of autophagy-related （Atg） genes required for autophagosome formation has led to the characterization of approximately 20 genes mediating this process. Recent structural studies of the Atg proteins have provided the molecular basis for their function. Here we summarize the recent progress in elucidating the structural basis for autophagosome formation.

关 键 词：MACROAUTOPHAGY AUTOPHAGY Atg proteins structural biology X-ray crystallography single-particle electronmicroscopy 

分 类 号：Q7[生物学—分子生物学] Q523