Joannesia princeps： Evaluation of Aqueous Extracts Genotoxicity Utilizing Allium cepa Assay and Micronucleus Test  

作　　者：Viviane Moreira de Lima Jessica Tamara dos Santos Teixeira Jennifer Vieira Gomes Lelio Kallut Almeida Netto Leonardo Oliveira Bastos Hataanderson Luiz Cabral dos Santos Lenicio Gongalves Francisco de Assis da Silva Bruno Pereira Berto Helcio Resende Borba 

机构地区：[1]Department of Animal Biology, Federal Rural University of Rio de Janeiro, Seropddica, Rio de Janeiro 23890000, Brazil

出　　处：《Journal of Life Sciences》2013年第12期1249-1254,共6页生命科学（英文版）

摘　　要：Evaluation of the genotoxic and cytotoxic potentials is a part of the analysis process where plant products with therapeutic properties must be submitted for being safely employed, mainly through long time points, doannesia princeps, also known as ＂cotieira＂ has been used on popular medicine as laxative and several diseases treatment. Aiming to analyze genotoxic potential ofd. princeps leaves extract, Allium cepa assay and micronucleus test were employed. No genotoxic activity presented J. princeps leaves extract; however, extracts cytotoxic activity over A. cepa meristematic cells and mice marrow cells was observed. J. princeps leaves extract presented antiproliferative activity at concentrations and systems employed indicating their therapeutic potential for cellular cycle inhibition. Moreover, results showed that in regard to its mutagenic effect, usage of J. princeps leaves tea on popular medicine has been a safe procedure, as well.

关 键 词：CYTOTOXICITY GENOTOXICITY Allium cepa assay MICRONUCLEUS Joannesia princeps. 

分 类 号：Q959.133[生物学—动物学] X835[环境科学与工程—环境工程]