COX-2和Ki67在鲍恩病皮损中的表达  

The expressions of COX-2 and Ki67 in Bowen's disease

作　　者：李丽丽[1] 朴冰[1] 崔英[1] 尤德渊[2] 

机构地区：[1]黑龙江省齐齐哈尔市第一医院皮肤科,161000 [2]哈尔滨医科大学附属第二医院皮肤科

出　　处：《实用皮肤病学杂志》2014年第2期107-109,共3页Journal of Practical Dermatology

摘　　要：目的研究COX-2和Ki67在鲍恩病皮损中的表达情况,并探讨两者之间的关系。方法应用免疫组化SP染色法对27例鲍恩病患者皮损及15份正常皮肤组织进行COX-2和Ki67染色。结果 COX-2与Ki67在正常皮肤组织中表达非常低,而在鲍恩病皮损中染色强度显著增高(P<0.05)。COX-2与Ki67在鲍恩病皮损中的表达水平呈显著正相关(r=0.451,P<0.05)。结论 COX-2与鲍恩病的发生密切相关,过度表达的COX-2蛋白可能参与肿瘤细胞的增生过程。Objective To study the expressions and relationship of COX-2 and Ki67 in Bowen’s disease. Methods Specimens from 27 Bowen＆#39;s disease patients and 15 normal persons were assayed for COX-2 and Ki67 by immunohistochemistry. Results The expressions of COX-2 and Ki67 in normal skin was very low, but in Bowen＆#39;s disease was signiifcantly increased. COX-2 was positive correlated with Ki67 in Bowen＆#39;s disease（r=0.451, P＆lt;0.05）. Conclusion The abnormal level of COX-2 and Ki67 plays a role in carcinogenesis and development of Bowen＆#39;s disease, the over-expression of COX-2 may result in the proliferation of tumor cell.

关 键 词：鲍恩病 COX-2 KI67 CYCLOOXYGENASE-2 KI67 

分 类 号：R739.5[医药卫生—肿瘤]