COX-2 3’非翻译区8473T>C变异与肝癌发病风险的关系  

Association of COX- 2 8473T > C genetic variant and risk of primary hepatic carcinoma

作　　者：邵莎莎[1] 付占昭[2] 王光霞[1] 宋琴琴 饶娟[4] 刘英文[4] 张志 

机构地区：[1]承德医学院,河北承德067000 [2]秦皇岛市第一医院肿瘤放化疗科 [3]唐山市工人医院肿瘤放化疗科 [4]河北联合大学生命科学学院

出　　处：《河北联合大学学报（医学版）》2014年第2期141-142,共2页Journal of North China Coal Medical College

基　　金：国家自然科学基金(编号:81101483);河北省杰出青年科学基金(编号:H2012401022)

摘　　要：①目的探讨环氧化酶2（COX-2）3’非翻译区的8473T＞C遗传变异与原发性肝癌遗传易感性的关系。②方法以 PCR-限制性片断长度多态性方法在270例肝癌病例和540例健康对照中进行基因分型。以Logistic回归计算基因型的病例-对照比值比（ OR）和95％可信区间（CI）。③结果 COX-23’非翻译区的8473T＞C遗传变异与原发性肝癌发病风险相关（ P ＜0．05）。 COX-2-8473CC基因型携带者与-8473TT基因携带者相比明显增加原发性肝癌发病风险，其OR和95％可信区间为2．56（1．37～4．79），存在统计学意义。④结论 COX-23’非翻译区的8473T＞C遗传变异与原发性肝癌发病风险密切相关。Objective To explore the relationship between 8473T＆gt;C genetic variant in the 3＆#39;UTR of COX-2 and the risk of primary hepatic carcinoma .Methods Total 270 primary hepatic carcinoma patients and 540 frequency-matched controls were selected in the study .The genotype of the COX -2 8473 T＆gt;C SNP was identified by polymerase chain reaction -restriction fragment length polymorphism method （PCR-RFLP）.Odds ratios （OR） and 95%confidence intervals （CI） were estimated by logistic re-gression .Resulst Case-control analysis showed that 8473 T＆gt;C polymorphism was associated with the risk of primary hepatic car-cinoma（ P ＆lt;0.05）.Compared with -8473TT carriers,-8473CC genotype carriers had a increased risk of primary hepatic carci-noma with OR（95%CI） of 2.56（1.37~4.79）.Conclusion COX2 8473 T＆gt;C polymorphism in 3＆#39;UTR of COX-2 was associat-ed with the development of primary hepatic carcinoma .

关 键 词：环氧化酶2 原发性肝癌 遗传变异 单核苷酸多态 CYCLOOXYGENASE-2 

分 类 号：R73[医药卫生—肿瘤]