抗炎镇痛药替尼达普钠的合成  

Synthesis of Anti-inflammatory and Analgesic Agents-Tenidap Sodium

作　　者：金熔[1] 刘嵘[1] 王尔华[1] 

机构地区：[1]中国药科大学医药化工研究所,南京210009

出　　处：《中国药科大学学报》2001年第1期70-72,共3页Journal of China Pharmaceutical University

基　　金：国家"九五"科技攻关项目! (96 -90 2 -0 1-0 7)

摘　　要：AIM: To synthesize anti inflammatory and analgesic agents Tenidap sodium. METHODS: Tenidap sodium was synthesized from 5 chloro 2 oxo 2,3 dihydro 1H indole 1 carboxamide(3) which was treated first with thenoyl chloride and then with sodium methoxide. The compound 3 was prepared from 5 chloro 2 oxindole by reacting successively with sodium methoxide, methyl chloroformate,ammonia. RESULTS: The overall yield was 30%. The structure of the product was confirmed by analysis. CONCLUSION: The reactions of all steps were carried out under very moderate conditions and suitable for a scale production.AIM: To synthesize anti inflammatory and analgesic agents Tenidap sodium. METHODS: Tenidap sodium was synthesized from 5 chloro 2 oxo 2,3 dihydro 1H indole 1 carboxamide(3) which was treated first with thenoyl chloride and then with sodium methoxide. The compound 3 was prepared from 5 chloro 2 oxindole by reacting successively with sodium methoxide, methyl chloroformate,ammonia. RESULTS: The overall yield was 30%. The structure of the product was confirmed by analysis. CONCLUSION: The reactions of all steps were carried out under very moderate conditions and suitable for a scale production.

关 键 词：替尼达普 抗炎镇痛药 合成 

分 类 号：R914[医药卫生—药物化学]