阿立哌唑治疗儿童青少年抽动障碍临床研究  

Clinical studies of aripiprazole in child and adolescent tic dis-order

作　　者：高蓉[1] 周渊东 黄自勇 金婷婷[1] 

机构地区：[1]苏州市广济医院,江苏苏州215008

出　　处：《临床心身疾病杂志》2014年第2期36-37,42,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的：探讨阿立哌唑治疗儿童青少年抽动障碍患者的临床疗效和安全性。方法对25例应用其他药物治疗效果不佳或耐受性较差的儿童青少年抽动障碍患者换用阿立哌唑治疗，观察10周。于治疗前后采用耶鲁抽动量表评定临床疗效，副反应量表评定不良反应。结果本组患者治疗10周末耶鲁抽动量表总分及运动抽动、发声抽动、功能损害评分均较基线显著下降（P＜0．01）；不良反应较轻微，主要表现为失眠、激越、头痛等。结论阿立哌唑治疗儿童青少年抽动障碍疗效显著，安全性高，依从性好。Objective To explore the efficacy and safety of aripiprazole in child and adolescent tic disorder . Methods Twenty-five tic disorder children and adolescents who had poor treatment effectiveness or toler-ance with other drugs were treated with aripiprazole for 10 weeks .Efficacies with assessed with the Yale Global Tic Severity Scale （YGTSS） before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale （TESS） .Results At the end of the 10th week total ,motor tic ,vocal tic and functional lesion score of the YGTSS lowered more significantly compared with pretreatment （P〈0 .01）;adverse reactions were mild and mainly insomnia ,agitation ,headache and so on .Conclusion Aripiprazole has an evident effect ,higher safety and better compliance in child and adolescent tic disorder .

关 键 词：抽动障碍 阿立哌唑 儿童 青少年 耶鲁抽动量表 副反应量表 

分 类 号：R749.94[医药卫生—神经病学与精神病学]