灵菊七脂溶性成分抑制α-葡萄糖苷酶活性及其成分分析  

GC-MS Analysis of Liposoluble Constituents from Gynura medica and Its α-Glucosidase Inhibitory Activity Investigation

作　　者：李凤伟[1] 杨文骏[1] 刘亚会[1] 杜杰[1] 徐乃江[1] 高健[1] 

机构地区：[1]盐城工学院,盐城224051

出　　处：《天然产物研究与开发》2014年第4期550-552,569,共4页Natural Product Research and Development

基　　金：盐城工学院人员引进项目(kjc2012035);江苏省高校自然科学研究项目(12KJD18007);江苏省高校科研成果产业化推进项目(JHB2012-52)

摘　　要：体外测定了灵菊七石油醚萃取物对α-葡萄糖苷酶的抑制作用,并采用GC-MS联用仪分析灵菊七石油醚萃取物的化学成分。结果表明,灵菊七石油醚萃取物对α-葡萄糖苷酶有较好的抑制活性,浓度在5 mg/mL时,对α-葡萄糖苷酶的抑制率为59.6%。经GC-MS分析从灵菊七石油醚萃取物中鉴定出17个化合物,占流出峰总面积的78.1%。石油醚萃取物中的萜类化合物可能是其抑制α-葡萄糖苷酶活性的主要物质。The α-glueosidase inhibitory activity of petroleum ether extracts of Gynura mediea was tested in vitro. The chemical components of the petroleum ether extracts of G. medica were analyzed by GC-MS. The results indicated that the petroleum ether extracts of G, mediea had a very good inhibitory activity,the inhibitory rate was 59.6% with the concen-tration of 5 mg/mL. Seventeen compounds composed 78.1% of the total peaks were separated and identified. The main constituents of petroleum ether extracts that inhibitied α-glueosidase may be terpennoids.

关 键 词：灵菊七 石油醚萃取物 气相色谱\质谱 抑制 Α-葡萄糖苷酶 

分 类 号：R93[医药卫生—生药学]