复合膳食纤维对大鼠急性胰腺炎时肠粘膜屏障的保护研究  

Protection of dietary fiber complex on rat intestinal mucosal barrier of acute pancreatitis

作　　者：张利东[1,2] 武华[3] 

机构地区：[1]山西医科大学,山西太原030001 [2]山西省清徐县人民医院普外科,山西清徐030400 [3]山西医科大学第一临床医学院普外科,山西太原030001

出　　处：《中国卫生产业》2014年第9期22-23,26,共3页China Health Industry

摘　　要：目的探讨复合膳食纤维(dietary fiber complex,DFC)在大鼠急性胰腺炎(acute pancreatitis,AP)时对肠粘膜屏障功能的作用。方法采用5%的牛黄胆酸钠(0.1mL/100mg)逆行注射入胰胆管法制备AP模型,44只大鼠随机分为4组,单纯模型组(A组),肠内营养剂(能全素)组(B组),能全素+复合膳食纤维[可溶性膳食纤维(SDF):不可溶性膳食纤维(IDF)=1:3](C组),能全素+复合膳食纤维[SDF:IDF=3:1](D组),分别于造模后12、24、48h时取门静脉及腹主动脉血并比较各时段各组大鼠血清中内毒素、D-乳酸的变化。结果 C组和D组血清内毒素和D-乳酸的释放低于A组和B组(P<0.05),B组血清内毒素和D-乳酸释放低于A组(P<0.05),C组内毒素和D-乳酸低于D组,但没有统计学意义(P>0.05)。结论复合膳食纤维对急性胰腺炎大鼠肠黏膜屏障功能有一定的保护作用。Objective To explore dietary fiber complex （DFC） on acute pancreatitis （AP）,s mechanism of action of the intestinal mucosal barrier. Methods AP rat model was established with 5% sodium taurocholate which was injected into pancreaticocholang retrogradely. 44 rats were randomly divided into four groups. Simple model group （group A）, Enteral Nutrition group （group B）, Nutrison ＋ composite dietary fiber [soluble dietary fiber （SDF）： insoluble dietary fiber （IDF） = 1：3] （Group C）, Nutrison ＋ composite dietary fiber [SDF： IDF = 3：1] （Group D）. Respectively extracted blood samples of rats＇ portal vein and aorta abdominalis then compared expression of endotoxin and D-lactic acid in the blood serum of rats in each group during 12h, 24h, 48h. Results The release of the group C and D in serum endotoxin and D-lactic acid is lower than in group A and group B （P〈0.05）.the release of the group B is lower than group A（P〈0.05）. the release of the group C is lower than group D, but the difference was not statistically significant（P〉0.05）.Conclusion DFC has a protective effect on gut barrier in rat with acute pancreatitis.

关 键 词：急性胰腺炎 大鼠 复合膳食纤维 能全素 内毒素 D-乳酸 

分 类 号：R576[医药卫生—消化系统]