IGF2R在非小细胞肺癌中的表达及与肿瘤进展的相关性研究  

Correlation study of IGF2R expression in non-small cell lung cancer and tumor progression

作　　者：张珉[1] 黄波[2] 张玲[1] 吕威力[1] 

机构地区：[1]沈阳医学院基础医学院病理教研室,沈阳110034 [2]辽宁省肿瘤医院病理科,沈阳110042

出　　处：《中国当代医药》2014年第12期12-14,共3页China Modern Medicine

摘　　要：目的探讨胰岛素样生长因子2受体(IGF2R)在非小细胞肺癌(NSCLC)组织中的表达情况与临床病理因素的关系。方法收集80例NSCLC组织及10例癌旁正常肺组织石蜡标本制成切片,利用免疫组织化学染色(SP)法检测IGF2R的表达,并分析其与各种临床病理因素的关系。结果 IGF2R主要定位于细胞膜及细胞质,80例NSCLC组织中,46例(57.5%)为高表达,在非癌性肺组织中弱表达或无明显表达。IGF2R表达同低级别pTNM分期(P=0.038)、局部淋巴结转移减少(P=0.021)相关。结论 IGF2R的表达与NSCLC低级别pTNM分期、局部淋巴结转移减少相关。Objective To explore the clinical significance of insulin-like growth factor 2 receptor （IGF2R） in patients with non-small cell lung cancer （NSCLC）. Methods Paraffin-embedded specimens from 80 patients with non-small cell lung cancer and 10 normal lung tissues adjacent to the cancer tissues were collected.The expressions of IGF2R protein were detected by immunohistochemistry,and its relationship with various clinical pathological factors was ana- lyzed. Results IGF2R mainly located in cell membrane and cytoplasm,among 80 lung cancer specimens,46 samples showed high expression levels of IGF2R （57.5%）,IGF2R was not detected or weakly positive stained in nonneoplastic lung specimens.High expression of IGF2R was correlated with low pTNM （P=0.038） and reduced lymph node metastasis （P= 0.021）. Conclusion High expression of IGF2R correlate with low pTNM and reduce lymph node metastasis in NSCLC.

关 键 词：胰岛素样生长因子2受体 非小细胞肺癌 肿瘤标志物 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]