抑郁症共病糖尿病患者血清同型半胱氨酸水平的对照研究  

Control Study on The Level of Serum Homocysteine in Depression Patients with Diabetes

作　　者：金梅[1] 陈方斌[1] 施建安[1] 徐乐平[1] 

机构地区：[1]中国 解放军第102医院精神科, 常州 213003

出　　处：《中国健康心理学杂志》2014年第4期487-489,共3页China Journal of Health Psychology

摘　　要：目的 对抑郁症共病糖尿病患者血清同型半胱氨酸水平（Hcy）进行对照研究.方法 首次确诊糖尿病的抑郁症患者（共病组,n =40）测定血清Hcy水平；同时测定空腹血糖（FPG）、糖负荷后2小时血糖（2hPG）、评定17项汉密尔顿抑郁量表（HAMD）,并与正常糖代谢状态的抑郁症患者（对照组,n=40）进行对照.结果 ①共病组血清Hcy水平[（20＆#177;6）μmol/L]显著高于对照组[（13＆#177;4） μmol/L],差异有统计学意义（t=6.139,P＜0.001）；②共病组高Hcy血症的发生率（62.5％）显著高于对照组（32.5％）,差异有统计学意义（x2 =7.218,P＜0.01）；③共病组、对照组的血清Hcy水平与FPG、2hPG、HAMD17评分均无显著的相关性（r =0.163～0.288,P均＞0.05）.结论 与正常糖代谢功能的抑郁症患者相比,伴发糖尿病的抑郁患者血清同型半胱氨酸水平显著增高.Objective To study the characteristics of serum homocysteine in depression patients with diabetes. Methods Two groups including depressed patients with newly diagnosed diabetes （ comorbidity group, n = 40）, depressed patients with normal glucose metabolism （ control group, n = 40） undertook serum homocysteine （ Hcy）, fasting plasma glucose （ FPG）, 2 h plasma glucose after 75 g glu- cose loading（ 2hPG） and HAMD17 measurement for a control study. Results The serum homocysteine level in comorbidity group was significantly higher than that in control group（ t = 6. 139 ,P 〈 0. 001 ）. The incidence of hyperhomocysteinemia was significantly higher in comorbidity group than in control group（x2 = 7. 218 ,P 〈0. 01 ）. Serum homocysteine level was not correlated with FPG,2hPG or score of HAMD 17 in either of two groups （ r = 0. 163 - 0. 288 ; all P 〉 0. 05 ）. Conclusion Compared to depressions with normal glucose metabo- lism, depressed patients with diabetes have increased level of serum homocysteine.

关 键 词：抑郁症 糖尿病 同型半胱氨酸 共病 精神病学 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R395.1[医药卫生—临床医学]