艾司西酞普兰与米氮平治疗老年性抑郁症的对照研究  

Escitalopram and Mirtazapine in the Treatment of Senile Depression

作　　者：陈晓刚[1] 周德祥[1] 张菁[1] 毛智群[1] 

机构地区：[1]中国 江苏省无锡市精神卫生中心精神科, 214151

出　　处：《中国健康心理学杂志》2014年第4期503-504,共2页China Journal of Health Psychology

摘　　要：目的观察艾司西酞普兰与米氮平治疗老年性抑郁症的疗效和安全性。方法对符合CCMD-Ⅲ的抑郁症诊断标准的60例老年患者,随机分为艾司西酞普兰组和米氮平组分别治疗。采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和副反应量表(TESS)分别观察疗效和不良反应,连续观察8周。结果在治疗第1周,两组HAMD和HAMA评分均下降,但两组间差异有显著性(t=6.44,3.81;P<0.05)。第2周末开始两组间HAMD和HAMA评分差异无显著性。第8周末两组显效率分别为73.3%和70.0%,差异无统计学意义。结论与米氮平相比,艾司西酞普兰治疗老年期抑郁症起效更快,病人的满意度和依从性更好。Objective To evaluate the efficacy and safety of escitalopram and mirtazapine in the treatment of senile depression. Methods A total of 60 elder patients met CCMD - Ⅲ depression diagnostic criteria were randomly divided into escitalopram group and mirtazapine group, respectively. Hamilton Depression Rating Scale （ HAMD）, Hamilton Anxiety Scale （HAMA） and Treatment Emergent Symptom Scale（TESS） were used to observe the effectiveness and adverse reactions for eight weeks. Results At the first treatment week- end, HAMD and HAMA scores were decreased in both groups and there were significant differences between two groups（ t = 6.44,3.81 ; P 〈 0.05）. After the second weekend, there were no significant differences between two groups in HAMD and HAMA scores （ t = 1.39, 0.71 ;P 〉 0.05）. At the eight weekend, the effective rate of two groups were 73.3% and 70.0% respectively, without statistical differ- ences. Conclusion Escitalopram shows the efficacy more rapidly,while its efficacy and adverse reactions are similar to mirtazapine.

关 键 词：艾司西酞普兰 米氮平 老年性抑郁症 精神病学 

分 类 号：R749.4[医药卫生—神经病学与精神病学] B845.4[医药卫生—临床医学]