季节气候变化对大鼠各肠段IL-2分泌的影响  

Influence of seasonal and climatic changes on interleukin-2 secretion in different intestinal sections

作　　者：王菁[1] 刘晓燕[1] 张兆国[1] 黄晓宇[1] 吴红倩[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《北京中医药大学学报》2014年第4期240-243,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(No.81001482);北京中医药大学气化学说与藏象理论研究创新团队资助项目(No.522/0100603001)

摘　　要：目的通过观察在中医五季下大鼠空肠、回肠和结肠分泌白细胞介素2(IL-2)量的不同,以揭示人体肠道适应季节气候变化的规律,为中医天人相应理论提供实验依据。方法以正常大鼠和松果腺摘除模型大鼠为研究对象,观察正常自然五季(春、夏、长夏、秋和冬)季节变化下,大鼠空肠、回肠和结肠的IL-2分泌水平变化以及摘除松果腺后的变化。结果正常组大鼠的空肠IL-2分泌水平在长夏季节最高,比其他4个季节有较为明显的差异(P<0.01);回肠表现在长夏和冬季较高,IL-2分泌水平均较春、夏和秋3季显著性升高(P<0.01,或P<0.05);结肠表现为在冬季的IL-2含量明显高于春、夏、长夏和秋这4个季节(P<0.01)。松果腺摘除后,各个肠段IL-2分泌的正常季节气候节律均出现了紊乱。结论空肠、回肠和结肠的IL-2分泌水平具有明显的季节气候节律性变化,与中医天人相应理论相吻合。松果腺参与了肠道功能的节律性调节过程。Objective To reveal the laws of human intestinal tract adapting seasonal and climate changes and provide invidence for TCM theory of correspondence between nature and human through observing different levels of intedeukin-2 （ IL-2 ） in rat jejunum, ileum and colon in five seasons of Chinese medicine. Methods Pinealectomized rat model was taken as study object, and the changes of IL-2 levels in rat jejunum, ileum and colon in five seasons （spring, summer, latter summer, autumn and winter） and changes after pinealectomizing were observed. Results In normal group, the level of IL-2 was higher in jejunum in latter summer compared with other 4 seasons （ P 〈 001 ）, higher in latter summer and winter in ileum compared with spring, summer and autumn （ P 〈 0.01 or P 〈 0.05 ） and higher in colon in winter compared with other 4 seasons （P 〈 0.01 ）. After pinealectomizing, the normal seasonal and climate rhythm of IL-2 secretion was disorder in all intestinal sections. Conclusion The level of IL-2 has seasonal and climate changes in rat jejunum, ileum and colon, which is consistent with TCM theory of correspondence between nature and human. The pineal gland takes part of the rhythmic regulation of intestinal function.

关 键 词：中医五季 气候 肠道 松果腺 白细胞介素-2 天人相应 大鼠 INTERLEUKIN-2 

分 类 号：R223.1[医药卫生—中医基础理论]