Citalopram increases the differentiation efficacy of bone marrow mesenchymal stem cells into neuronal-like cells  

作　　者：Javad Verdi Seyed Abdolreza Mortazavi-Tabatabaei Shiva Sharif Hadi Verdi Alireza Shoae-Hassani 

机构地区：[1]Department of Applied Cell Sciences,School of Advanced Technologies in Medicine,Tehran University of Medical Sciences [2]Department of Stem Cells and Tissue Engineering,Research Center for Science and Technology in Medicine,Tehran University of Medical Sciences [3]Department of Tissue Engineering,School of Advanced Technologies in Medicine,Iran University of Medical Sciences

出　　处：《Neural Regeneration Research》2014年第8期845-850,共6页中国神经再生研究（英文版）

基　　金：funded by the Research Center for Science and Technology in Medicine(RCSTiM),Tehran University of Medical Sciences,Tehran(TUMS),Tehran,Iran

摘　　要：Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was signiifcantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These ifndings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics.Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was signiifcantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These ifndings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics.

关 键 词：nerve regeneration CITALOPRAM stem cells bone marrow mesenchymal stem cells survival proliferation DIFFERENTIATION NEURONS neural regeneration 

分 类 号：R741[医药卫生—神经病学与精神病学]