右佐匹克隆对急性低压低氧小鼠戊巴比妥钠睡眠时间和自发活动的影响  

Effect of eszopiclone on pentobarbital sodium-induced sleeping time in acute hypobaric hypoxia mice

作　　者：钟玲[1] 宋永斌[2] 杨俊[2] 蔡倩[2] 徐江涛[2] 

机构地区：[1]新疆石河子大学医学院,石河子832000 [2]兰州军区乌鲁木齐总医院神经内科

出　　处：《中华行为医学与脑科学杂志》2014年第4期307-309,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：全军“十一五”计划课题项目（06MB106）

摘　　要：目的 评估右佐匹克隆（Eszopiclone,ESZ）对急性低压低氧小鼠戊巴比妥钠睡眠时间及自发活动的影响.方法 按药物分0.9％氯化钠注射液（NS）和ESZ 2个水平及按海拔分800 m、3500 m和6000 m水平的2×3析因实验设计,将120只小鼠随机分为6组,进行戊巴比妥钠睡眠时间实验和旷场实验.结果 （1）析因分析表明,药物和海拔对戊巴比妥钠睡眠时间实验和旷场实验的结果均无交互作用（P＞0.05）.（2）800 m、3500 m、6000 m海拔下ESZ组戊巴比妥钠睡眠时间分别为（37.77± 18,22） min,（37.02±13.67） min,（95.67±47.68） min,NS组戊巴比妥钠睡眠时间分别为（17.78± 14.10） min,（15.09± 12.46） min,（39.54±28.24） min,ESZ组睡眠时间均较相应海拔的NS组延长（P＜0.05）;6000 m海拔的ESZ组和NS组均较800 m和3500 m海拔相应用药组延长（P＜0.05）.（3）旷场实验显示,相同海拔NS与ESZ组间比较差异无统计学意义（P＞0.05）;6000m海拔NS组和ESZ组小鼠用药6h后自发活动较800 m海拔相应用药组减少（P＜0.05）.结论 ESZ延长低压低氧小鼠戊巴比妥钠睡眠时间,且6000 m海拔条件下效果最明显.但不影响用药6h后小鼠自发活动;6000 m海拔低压低氧延长戊巴比妥钠睡眠时间,减少小鼠自发活动.Objective To assess the effects of eszopiclone （ESZ） on the pentobarbital sodium-induced sleeping time and spontaneous activity in mice exposed to acute hypobaric hypoxia.Methods 120 mice were randomly divided into 6 groups by using two factors 2×3 levels factorial design,in which two factors were interventions （ESZ and 0.9% sodium chloride,2 levels） and altitudes （800 m,3500 m and 6000 m,3 levels）.The pentobarbital sodium-induced sleeping test and the open field test were engaged to assess the effects of ESZ on sleeping time and spontaneous activity.Results （1） The drug and altitude had no interaction in the results of both the pentobarbital sodium-induced sleeping test and the open field test（P〉0.05）.（2）The time of pentobarbital sodium-induced sleeping of mice in the groups of ESZ at each altitudes were （37.77± 18.22） min,（37.02± 13.67） min,（95.67±47.68）min and in the groups of NS were（17.78± 14.10） min,（15.09± 12.46） min,（39.54±28.24） min respectively,and the sleep time in ESZ groups were significantly longer than those in the groups of NS （P〈0.05）.The time of pentobarbital sodium-induced sleeping were longer in group of 6000 m than those in the other two groups,both the ESZ and NS groups （P〈0.05）.（3）No significant difference was found in the open field test between the ESZ and NS groups in the same altitude（P〉0.05） ; while the mice at the altitude of 6000 m in groups of ESZ and NS decreased compared with the groups at the altitude of 800 m after the relevant drugs intra-perineally for 6 h （P〈0.05）.Conclusion ESZ may prolong pentobarbital sodium-induced sleeping time especially at the altitude of 6000 m and with no influence on the spontaneous activity in mice exposed to acute hypobaric hypoxia.High altitude at 6000 m may prolong the sleep time induced by pentobarbital sodium and reduce the spontaneous activities.

关 键 词：右佐匹克隆 低压低氧 睡眠时间 自发活动 

分 类 号：R740[医药卫生—神经病学与精神病学]