青少年近视与血清性激素关系分析  

Analysis on the relationship between adolescent myopia and serum sex hormone

作　　者：谢红莉[1] 毛欣杰[2] 杨海虹[3] 谢作楷[3] 潘妤[1] 高扬[4] 

机构地区：[1]温州医科大学公共政策与社会发展研究所、浙江省流行病与卫生统计学重点学科, 浙江省325035 [2] 温州医科大学附属眼视光医院 [3] 温州医科大学附属第二医院 [4] 温州医科大学第一临床医学院临床医学系

出　　处：《中华医学杂志》2014年第17期1294-1297,共4页National Medical Journal of China

基　　金：浙江省自然科学基金（LY12H12002）

摘　　要：目的 探讨青少年近视患者血清性激素的变化.方法 2013年1月在温州瓯海区某中学调查822例学生,其中男生432例,女生390例,设视力≥5.0为正常,分为近视组与非近视组,再用化学发光免疫分析仪分别检测上述2组青少年空腹血清的雌二醇（E2）、睾丸酮（T）、促卵泡刺激素（FSH）、黄体生成素（LH）4项性激素浓度.结果 男性、女性促卵泡刺激素水平差异有统计学意义（Z=12.9,P＜0.01）,同时结合二者的平均水平,判断女性（均值为6.87）高于男性（均值为5.06）;男性、女性促黄体生成素差异有统计学意义（Z=9.3,P＜0.01）,同时结合二者的平均水平,判断女性（均值为7.39）显著高于男性（均值为1.96）.女性近视与非近视两组促黄体生成素水平差异有统计学意义（Z=-2.45,P＜0.05）,同时结合两组的均值水平,判断近视组（均值为8.21）大于非近视组（均值为5.54）;女性近视与非近视两组促卵泡刺激素水平差异性有统计学意义（Z=-2.91,P＜0.05）,同时结合两组的均值水平,判断近视组（均值为7.27）大于非近视组（均值为5.96）.男性近视组与非近视组间促黄体生成素水平差异有统计学意义（Z=-2.84,P＜0.01）,同时结合两组的均值水平,判断近视组（均值为2.06）大于非近视组（均值为1.78）;两组睾丸酮水平差异有统计学意义（Z=-2.6,P＜0.01）,同时结合两组的均值水平,判断近视组（均值为2.11）大于非近视组（均值为1.79）.结论 血清中性激素水平的高低及性别差异与青少年近视的发生与发展可能存在一定关联.Objective To investigate the quantitative changes of the serum sex hormone levels in juvenile myopia patients.Methods In January 2013,investigation of wenzhou middle school 822 adolescents,including 432 male patients and 390 female patients were involved in the study Visual acuity ≥ 5 was set as the normal value.The subjects were divided into two groups,the myopia group and the non-myopia group.Chemiluminescence immunoassay analyzer was used to detect the subjects＆#39; sex hormone concentration of estradiol （E2）,testosterone （T）,follicle stimulating hormone （FSH） and luteinizing hormone （LH）.Results The follicle stimulating hormone and luteinizing hormone of the female patients were significantly higher than those of male counterparts （P 〈 0.01） ; among the two groups consisting female myopia and non-myopia patients,a significant difference in luteinizing hormone and follicle stimulating hormone was shown （P 〈 0.05） ; the distinct differences in the level of luteinizing hormone and testosterone level showed in the male myopia group and non-myopia group were of outstanding statistics significance （P 〈0.01）,showing the result that the level of sex hormone in myopia group was higher than that in the non-myopia group.Conclusion A close relationship perhaps between the level of sex hormone with gender differences and juvenile myopia is confirmed.

关 键 词：近视 性激素 临床研究 青少年 

分 类 号：R778.11[医药卫生—眼科]