Progress on the M-type phospholipase A2 receptor in idiopathic membranous nephropathy  

作　　者：Wang Chao Lu Huan Yang Cui Luo Yuezhong 

机构地区：[1]Department of Nephrology First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China [2]Guangzhou University of Chinese Medicine, Guangzhou, Guangdong510405, China [3]Department of Echocardiography First Affiliated Hospital of GuangzhouUniversity of Chinese Medicine, Guangzhou, Guangdong 510405,China

出　　处：《Chinese Medical Journal》2014年第10期1960-1963,共4页中华医学杂志（英文版）

基　　金：This study was supported by a grant from the National Science Foundation of China （No. 81373568）.

摘　　要：Objective To highlight current knowledge about M-type phospholipase A2 receptor （PLA2R） which is the first human autoantigen discovered in adult idiopathic membranous nephropathy.Data sources Relevant articles published in English from 2000 to present were selected from PubMed.Searches were made using the terms ＂idiopathic membranous nephropathy,M-type PLA2R and podocyte.＂ Study selection Articles studying the role of M-type PLA2R in idiopathic membranous nephropathy were reviewed.Articles focusing on the discovery,detection and clinical observation of anti-PLA2R antibodies were selected.Results M-type PLA2R is a member of the mannose receptor family of proteins,locating on normal human glomeruli as a transmembrane receptor.The anti-PLA2R in serum samples from MN were primarily IgG4 subclass.Technologies applied to detect anti-PLA2R autoantibody are mainly WB,lIFT,ELISA and so on.Studies from domestic and overseas have identified a strongly relationship between circulating anti-PLA2R levels and disease activity.Conclusion Recent discoveries corresponding to PLA2R facilitate a better understanding on IMN pathogenesis and may provide a new tool to its diagnosis,differential diagnosis,risk evaluation,response monitoring and patient-specific treatment.Objective To highlight current knowledge about M-type phospholipase A2 receptor （PLA2R） which is the first human autoantigen discovered in adult idiopathic membranous nephropathy.Data sources Relevant articles published in English from 2000 to present were selected from PubMed.Searches were made using the terms ＂idiopathic membranous nephropathy,M-type PLA2R and podocyte.＂ Study selection Articles studying the role of M-type PLA2R in idiopathic membranous nephropathy were reviewed.Articles focusing on the discovery,detection and clinical observation of anti-PLA2R antibodies were selected.Results M-type PLA2R is a member of the mannose receptor family of proteins,locating on normal human glomeruli as a transmembrane receptor.The anti-PLA2R in serum samples from MN were primarily IgG4 subclass.Technologies applied to detect anti-PLA2R autoantibody are mainly WB,lIFT,ELISA and so on.Studies from domestic and overseas have identified a strongly relationship between circulating anti-PLA2R levels and disease activity.Conclusion Recent discoveries corresponding to PLA2R facilitate a better understanding on IMN pathogenesis and may provide a new tool to its diagnosis,differential diagnosis,risk evaluation,response monitoring and patient-specific treatment.

关 键 词：membranous nephropathy receptors  phospholipase A2 AUTOANTIGEN PODOCYTES 

分 类 号：R692.3[医药卫生—泌尿科学]