AUTOANTIGEN

作品数：12被引量：78H指数：4
导出分析报告
相关领域：医药卫生生物学更多>>
相关作者：张镜宇黄鹤甘一如黄真陈鹏更多>>
相关机构：第三军医大学北京大学第一医院北京科技大学天津医科大学更多>>
相关期刊：《Chinese Medical Journal》《Transactions of Tianjin University》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金上海市自然科学基金北京市自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Autoimmune diseases: targets, biology, and drug discovery被引量：1
《Acta Pharmacologica Sinica》2024年第4期674-685,共12页Shu-jie Li Yan-li Wu Juan-hua Chen Shi-yi Shen Jia Duan H.Eric Xu 
supported by CAS Strategic Priority Research Program (XDB37030103 to HEX);Shanghai Municipal Science and Technology Major Project (2019SHZDZX02 to HEX);Shanghai Municipal Science and Technology Major Project (HEX);The National Natural Science Foundation of China (32130022, 82121005);the Lingang Laboratory Grant (LG-GG-202204-01 to HEX);the National Key R&D Program of China (2018YFA0507002 to HEX).
Autoimmune diseases (AIDs) arise from a breakdown in immunological self-tolerance, wherein the adaptive immune system mistakenly attacks healthy cells, tissues and organs. AIDs impose excessive treatment costs and cur...
关键词：autoimmune disease AUTOANTIGEN IMMUNOTHERAPY type 1 diabetes INSULIN drug discovery 
Identification of lipopolysaccharide-binding protein as a novel citrullinated autoantigen in rheumatoid arthritis
《Rheumatology & Autoimmunity》2022年第1期5-14,共10页Xiaozhen Zhao Yuling Chen Wen Wen Yongjing Cheng Ru Li Xu Liu Yuhui Li Rulin Jia Haiteng Deng Zhanguo Li Xiaolin Sun 
Peking University People's Hospital Research and Development Funds,Grant/Award Number:RDX2019-03;National Natural Science Foundation of China,Grant/Award Numbers:81971520,U1903210,81671602;Beijing Municipal Science and Technology Project,Grant/Award Numbers:Z191100006619112,Z191100006619110。
Background:A specific feature of the autoimmune response in rheumatoid arthritis(RA)is the presence of anti-citrullinated protein antibodies(ACPAs)in patient sera.These antibodies can appear several years before disea...
关键词：ACPA lipopolysaccharide-binding protein RHEUMATOID ARTHRITIS 
Autoantigen Microarray for High-throughput Autoantibody Profiling in Systemic Lupus Erythematosus被引量：6
《Genomics, Proteomics & Bioinformatics》2015年第4期210-218,共9页Honglin Zhu Hui Luo Mei Yan Xiaoxia Zuo Quan-Zhen Li 
supported by the National Natural Science Foundation of China(Grant No.81270852)
Systemic lupus erythematosus （SLE） is a complex autoimmune disease characterized by the production of autoantibodies to a broad range of self-antigens. Profiling the autoantibody repertoire using array-based technol...
关键词：Systemic lupus erythemato-sus（SLE） Autoantibody profiling Proteomic microarray BIOMARKER High-throughput assay 
Progress on the M-type phospholipase A2 receptor in idiopathic membranous nephropathy被引量：10
《Chinese Medical Journal》2014年第10期1960-1963,共4页Wang Chao Lu Huan Yang Cui Luo Yuezhong 
This study was supported by a grant from the National Science Foundation of China （No. 81373568）.
Objective To highlight current knowledge about M-type phospholipase A2 receptor （PLA2R） which is the first human autoantigen discovered in adult idiopathic membranous nephropathy.Data sources Relevant articles publi...
关键词：membranous nephropathy receptors  phospholipase A2 AUTOANTIGEN PODOCYTES 
Autoimmune liver serology:Current diagnostic and clinical challenges被引量：40
《World Journal of Gastroenterology》2008年第21期3374-3387,共14页Dimitrios P Bogdanos Diego Vergani Pietro Invernizzi Ian R Mackay 
Liver-related autoantibodies are crucial for the correct diagnosis and classification of autoimmune liver diseas-es(AiLD),namely autoimmune hepatitis types 1 and 2(AIH-1 and 2),primary biliary cirrhosis(PBC),and the s...
关键词：AUTOANTIGEN Autoimmune hepatitis AUTO-ANTIBODY Primary biliary cirrhosis Primary sclerosing cholangitis Liver disease 
Human LINE1 endonuclease domain as a putative target of SARS-associated autoantibodies involved in the pathogenesis of severe acute respiratory syndrome被引量：1
《Chinese Medical Journal》2008年第7期608-614,共7页HE Wei-ping SHU Cui-li LI Bo-an ZHAO Jun CHENG Yun 
This study was supported by grants from the National Natural Science Foundation of China （No. 30340010） and the Natural Science Foundation of Beijing （No. 7034050）.
Background Severe acute respiratory syndrome （SARS） is a disease with a mortality of 9.56%. Although SARS is etiologically linked to a new coronavirus （SARS-CoV） and functional cell receptor has been identified, t...
关键词：severe acute respiratory syndrome AUTOANTIBODY AUTOANTIGEN PATHOGENESIS 
Autoantigen administration confers diabetes-preventive properties to NOD mice derived dendritic cells
《Journal of Microbiology and Immunology》2007年第1期69-77,共9页MING XIANG XIAO LEI ZOU JING XU YAO YAO JIN FANG ZHANG 
This study was supported by the National Natural Science Foundation of China(No.30200343).
Administration of autoantigen can be of value for prevention of autoimmune diabetes and it has been speculated that the control point of dendritic cells(DC)for the induction of peripheral toler- ance may be highly rel...
关键词：Diabetes Dendritic cells Immune tolerance NOD mice 
Characterization of human gene encoding SLA/LP autoantigen and its conserved homologs in mouse,fish,fly,and worm被引量：1
《World Journal of Gastroenterology》2006年第6期902-907,共6页Chun-Xia Wang Andreas Teufel Uta Cheruti Joachim Groetzinger Peter R Galle Ansgar W Lohse Johannes Herkel 
Supported by the Deutsche Forschungsgemeinschaft(SFB 548)
AIM： To approach the elusive function of the SLA/LP molecule, we have characterized genomic organization and conservation of the major antigenic and functional properties of the SLA/LP molecule in various species. ME...
关键词：Autoimmune hepatitis AUTOANTIGEN GENOMICS Bioinformatics 
Construction and expression of a humanized M_2 autoantigen trimer and its application in the diagnosis of primary biliary cirrhosis被引量：17
《World Journal of Gastroenterology》2003年第6期1352-1355,共4页Xiao-HuaJiang Ren-QianZhong Sheng-QianYu YinHu Weng-WengLi Xian-TaoKong 
AIM: To construct and express a humanized M2 autoantigen trimer designated as BPO and to apply it in the diagnosis of primary biliary cirrhosis (PBC). METHODS: cDNA fragments encoding M2-reactive epitopes of pyruvate ...
关键词：原发性胆汁性肝硬变 诊断 胆汗磷脂排出量 M2抗原 
Expression and identification of type 1 diabetes associated autoantigen IA-2被引量：2
《Chinese Medical Journal》2003年第4期524-528,共5页贾秀娟 李果 陈战 许光武 谢超 张迪 周文中 郑升 谢晓雁 杨键 李纪平 罗敏 
ThisworkwassupportedbythegrantsfromShanghaiHealthOfficeTechnologyDevelopmentFoundation(No00418)andShanghaiHighSchoolNaturalScienceResearchFoundation (No 2 0 0 0B1 6)
s To obtain prokaryotic expressed IA-2 recombinant protein and to identify its immunological activity Methods The complimentary DNA (cDNA) coding for the intracytoplasmic part of IA-2 (IA-2ic) was amplified from hu...
关键词：type 1 diabetes IA-2 autoant igen AUTOANTIBODIES 
全选清除导出
共2页<12>
检索报告 对象比较 聚类工具 使用帮助 返回顶部