Duchenne型肌营养不良认知障碍机制研究进展  

Mechanisms of Cognitive Impairment of Duchenne's Muscular Dystrophy(review)

作　　者：付雅[1] 吴士文[1] 

机构地区：[1]安徽医科大学武警总医院临床学院,北京市100039

出　　处：《中国康复理论与实践》2014年第5期451-454,共4页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：Duchenne型肌营养不良是一种常见的X染色体连锁隐性遗传神经肌肉病,并常伴有认知障碍。目前关于其认知障碍机制研究较多,主要集中在抗肌萎缩蛋白亚型缺乏、中枢神经系统发育异常、突触功能改变、血脑屏障改变、大脑代谢改变及小脑功能异常等。Duchenne＇s muscular dystrophy （DMD） is a common X-linked recessive neuromuscular disorder that associated with a spec-trum of genetically based cognitive and behavioral disabilities. Several mechanisms have been discussed as the cause of cognitive impair-ment in patients with DMD： absence of different dystrophin isoforms, impairments in neurogenesis, changes of synaptic plasticity,blood-brain barrier alterations, brain metabolic differences, cerebellum disfunction, etc.

关 键 词：DUCHENNE型肌营养不良 认知障碍 抗肌萎缩蛋白 突触 血脑屏障 代谢 小脑 综述 

分 类 号：R746[医药卫生—神经病学与精神病学]