氨基葡萄糖基吡啶基脲类化合物的合成  

The synthesis of glucosamine pyridylureas derivates

作　　者：陈宇[1] 洪碧红[1,2] 黄文文[1] 陈永强[1] 易瑞灶[1] 

机构地区：[1]国家海洋局第三海洋研究所,福建厦门361005 [2]厦门大学化学化工学院材料科学与工程系,福建厦门361005

出　　处：《中国海洋药物》2014年第3期81-84,共4页Chinese Journal of Marine Drugs

基　　金：海洋公益性行业科研专项(201405016)资助

摘　　要：目的设计简便高效的合成路线,合成新型糖基吡啶基脲类化合物。方法采用异氰酸酯法,以D-氨基葡萄糖盐酸盐为原料,乙酰化合成1,3,4,6-四-O-乙酰基-α-D-氨基葡萄糖硫酸盐,在三光气的作用下与氨基吡啶反应得到糖基吡啶基脲,并用IR、1 H NMR、13 C NMR及质谱对合成样品进行表征。结果得到了6个未见文献报导的糖基吡啶基脲类化合物,且确证了6个新化合物的结构。结论该合成方法工艺简单,操作易行,进一步发展了异氰酸酯法的脲合成,可望用来合成一系列含取代基的糖基吡啶基脲类物质。Objective To create a convenient and efficient synthetic route to get new sugar pyridylureas. Methods 1,3,4, 6-tetra-O-acetyl-α-D-glucosamine sulfate was prepared by direct acetylation of D-glu- cosamine hydrochloride with acetic anhydride. Olucosamine pyridylureas derivates could be prepared by using the method of isocyanate. The products were identified by IR, 1H NMR,13 C NMR and MS. Results Six new sugar pyridylureas were prepared and their structures were confirmed. Conclusion This synthetic method can be expected to synthesize a series of sugar pyridylureas containing substituting group on the sugar ring. It is indicated that the synthetic method is simple and very easy to operate.

关 键 词：氨基葡萄糖盐酸盐 氨基吡啶 糖基吡啶基脲 

分 类 号：R914[医药卫生—药物化学]