乙二醛酶Ⅰ基因rs1049346 G/A多态性与耐药性癫痫的相关性  

Association study on glyoxalase Ⅰ polymorphisms and drug-resistant epilepsy

作　　者：刘洲[1] 崔理立[1] 蔡玉洁[1] 许志恩[1] 李克深[1] 赵斌[1] 

机构地区：[1]广东医学院附属医院神经内科, 524001

出　　处：《神经疾病与精神卫生》2014年第2期140-143,共4页Journal of Neuroscience and Mental Health

摘　　要：目的 探讨乙二醛酶Ⅰ （Glo Ⅰ）基因rs1049346 G/A多态性和耐药性癫痫的相关性.方法 收集67例汉族耐药性癫痫患者和69例汉族非耐药性癫痫患者.采用SNaPshot方法检测患者外周血Glo Ⅰ基因rs1049346 G/A多态性.结果 耐药组GG、GA、AA基因型分别占6.0％,49.3％,44.7％,非耐药组分别占7.2％,53.6％,39.1％,总体差异无统计学意义（χ^2=0.46,P=0.79）.耐药组等位基因G、A频率分别为30.6％,69.4％,非耐药组患者分别为34.1％,65.9％,差异也无统计学意义（OR =0.85,95％ CI 0.51-1.42,χ^2=0.37,P=0.54）.结论 Glo Ⅰ基因rs1049346 G/A多态与汉族癫痫耐药可能无相关性.Objective To investigate the correlation of glyoxalase Ⅰ （Glo Ⅰ 〉 gene rs1049346 G/A and drug--resistant epilepsy （DRE）. Methods The associations between rs1049346 polymorphisms of the Glo Ⅰ gene and the possible risk of DRE were assessed among 67 patients with DRE and 69 matched patients with non--drug-- resistant epilepsy （NDRE） of Han in a case--control study. Results GG, GA, AA genotypes accounted for 6.0% ,49.3% ,44.7%, and 7.2% ,53.6% ,39.1% in DRE group and NDRE group respectively （χ^2 = 0.46,P = 0.79）. Allele G, A frequencies were 30. 6%, 69.4% and 34.1%,65.9% inDREgroup and NDRE group respectively （OR = 0.85, 95% CI 0.51 1.42, Z2 = 0. 37,P = 0.54）. Conclusions Maybe there is no association between rs1049346 G/A polymorphism of Glo Ⅰ gene and DRE in Han.

关 键 词：耐药性癫痫 乙二醛酶Ⅰ 基因多态性 

分 类 号：R742.1[医药卫生—神经病学与精神病学]