Paracrine signaling in stem cell renewal and in neoplastic tumor growth  

作　　者：ZHAO Chen 

机构地区：[1]Department of Developmental Biology,Stanford University

出　　处：《Science China(Life Sciences)》2014年第6期571-574,共4页中国科学（生命科学英文版）

摘　　要：Paracrine pathway activities are being increasingly recognized as instrumental regulatory mechanisms of epithelial-stromal interactions that play important roles in physiological and pathological self-renewal of stem cells and in the initiation and maintenance of neoplastic tumor development.Stromal-specific Hedgehog(Hh)responses and epithelial-associated Wnt pathway activities have been recently appreciated as important factors in stem cell self-renewal and carcinogenesis.Furthermore,Hh and Wnt pathways frequently crosstalk with each other to regulate the growth of epithelial cells in a context-dependent manner.Because small molecule modulators of Hh and Wnt pathway activities are readily available,emerging roles of Hh-Wnt pathway crosstalk in epithelial-stromal interactions will shed light on the development of regenerative and anti-cancer medicines.Paracrine pathway activities are being increasingly recognized as instrumental regulatory mechanisms of epithelial-stromal interactions that play important roles in physiological and pathological self-renewal of stem cells and in the initiation and maintenance of neoplastic tumor development. Stromal-specific Hedgehog（Hh） responses and epithelial-associated Wnt pathway activities have been recently appreciated as important factors in stem cell self-renewal and carcinogenesis. Furthermore,Hh and Wnt pathways frequently crosstalk with each other to regulate the growth of epithelial cells in a context-dependent manner. Because small molecule modulators of Hh and Wnt pathway activities are readily available,emerging roles of Hh-Wnt pathway crosstalk in epithelial-stromal interactions will shed light on the development of regenerative and anti-cancer medicines.

关 键 词：HEDGEHOG Wnt PARACRINE stem cell tumor 

分 类 号：R730.2[医药卫生—肿瘤]