2,4-二氯苯氧乙酸的致突变性研究  

Study on mutagenicity of 2,4-dichlorophenoxyacetic acid

作　　者：薄存香[1] 刘永霞[1] 戈扬[1] 张振玲[1] 谢琳[1] 

机构地区：[1]山东省职业卫生与职业病防治研究院,山东济南250002

出　　处：《癌变．畸变．突变》2014年第1期68-70,共3页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：山东省自然科学基金项目(ZR2012CL12);山东省医学科学院科技项目(2011013)

摘　　要：目的:研究2,4-二氯苯氧乙酸(2,4-D)是否具有潜在的遗传毒性。方法:利用Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠睾丸初级精母细胞染色体畸变试验对2,4-D原药的致突变性进行研究。结果:与对照组比较,2,4-D原药各剂量组对TA97、TA98、TA100和TA102菌株均无诱发回复突变菌落数增加的作用(P>0.05),对小鼠骨髓嗜多染红细胞的微核细胞率亦无明显影响(P>0.05),也未引起小鼠睾丸初级精母细胞染色体畸变率明显改变(P>0.05)。结论:在本实验条件下,未发现2,4-D原药的致突变性。OBJECTIVE： To explore the potential mutagenicity of 2,4-dichlorophenoxyacetic acid. METHODS：Ames test,mouse bone marrow micronucleus test and mouse primary spermatocyte chromosome aberration test were conducted. RESULTS：Ames test showed no two-fold increase in the spontaneous reversion colonies compared with the negative control group （P〉0.05）. No significant difference was found in chromosome aberration and micronucleus rate between control and experimental groups （P〉0.05）. CONCLUSION：2,4-dichlorophenoxyacetic acid showed no mutagenicity under these test conditions.

关 键 词：2 4-二氯苯氧乙酸 AMES试验 染色体畸变 微核 突变 

分 类 号：R994.3[医药卫生—毒理学] R482.4[医药卫生—药学]