1种五肽(IIAEK)对喂食高脂高胆固醇小鼠脂质代谢的影响  

Effects of Peptide(IIAEK) on Lipid Metabolism of Mice Fed High Fat and Cholesterol Diet

作　　者：张慧娟[1] 王静[1] 刘英丽[1] 

机构地区：[1]北京工商大学食品学院,北京100048

出　　处：《中国食品学报》2014年第4期10-14,共5页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家自然科学基金项目(31271976);"十二五"国家科技支撑计划项目(2012BAD34B05);北京市属高等学校高层次人才引进与培养计划项目(CIT&TCD20130309;IDHT20130506);国家高技术研究发展(863)计划项目(2012AA021502)

摘　　要：以喂食高脂高胆固醇饲料的雄性小鼠为动物模型,研究来源于牛奶β-乳球蛋白的多肽IIAEK灌胃小鼠3周对小鼠脂质代谢的影响。试验结果表明:与对照组相比,多肽使小鼠血浆中总胆固醇含量显著增加了30%;使肝脏中的总脂肪含量显著增加了24%,使小鼠肝脏中总胆固醇含量显著降低了24%;同时多肽使小鼠粪便中的总胆固醇含量显著增加了23%,使粪便中的胆汁酸含量显著降低了36%。以上结果表明多肽IIAEK对喂食高脂、高胆固醇饲料的雄性小鼠的脂质代谢的调节作用不明显。This study investigated effects of a pentapeptide from milk β-globulin on lipoprotein metabolism in male mice fed high-fat and -cholesterol diets. After orally administered for 3 weeks, the plasma total cholesterol content was significantly reduced 30% in peptide supplemented diet group. The supplement of peptide significantly increased the hep- atic total lipid content （24%）, but significantly reduced the hepatic total cholesterol content （24%）. Moreover, IIAEK sig nificantly increased the fecal total cholesterol excretion （23%）, but significantly reduced the fecal bile acid content （36%）. The results of this study showed that IIAEK did not significantly affect the lipoprotein metabolism in male mice.

关 键 词：多肽 小鼠 胆固醇 胆汁酸 

分 类 号：Q493.5[生物学—生理学]