α-黑色素细胞刺激素的抗炎机制  

The anti-inflammatory mechanisms of α-melanocyte-stimulating hormone

作　　者：陈波[1] 胡巢凤[1] 王华东[1] 林晨[2] 李楚杰[1] 

机构地区：[1]暨南大学医学院病理生理学教研室,广东广州510632 [2]暨南大学医学院微生物学与免疫学教研室,广东广州510632

出　　处：《中国病理生理杂志》2001年第3期281-284,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目 (No .395 0 0 0 5 9)

摘　　要：α-MSH is an endogenous neuropetide that is effective of all categories of expreimental inflammation. The mechanisms underlying the anti-inflammatory influence of α-MSH are reviewed in the article. α-MSH suppresses inflammation in the CNS and periphery by downregulating the activation of NF-κB, then inhibiting production of proinflammatory cytokines, nitric oxide, chemokines and adhension molecules, and increasing synthesis of anti-inflammatory cytokines. α-MSH is useful in the treatment of many pathological situations in humans.α-MSH is an endogenous neuropetide that is effective of all categories of expreimental inflammation. The mechanisms underlying the anti-inflammatory influence of α-MSH are reviewed in the article. α-MSH suppresses inflammation in the CNS and periphery by downregulating the activation of NF-κB, then inhibiting production of proinflammatory cytokines, nitric oxide, chemokines and adhension molecules, and increasing synthesis of anti-inflammatory cytokines. α-MSH is useful in the treatment of many pathological situations in humans.

关 键 词：MSH 细胞活素类 NF-KB 炎症 

分 类 号：R364.5[医药卫生—病理学]