Incorporation of Lysine-Containing Copolymer with Polyurethane Affording Biomaterial with Specific Adsorption of Plasminogen  

作　　者：Haichao Xu Yafei Luan Zhaoqiang Wu Xinming Li Yuling Yuan Xiaoli Liu Lin Yuan Dan Li Hong Chen 

机构地区：Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, China Email: Dan Li ([e-mail]), Hong Chen ([e-mail])[*]Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, China, Tel.: [phone] Fax: [phone]

出　　处：《Chinese Journal of Chemistry》2014年第1期44-50,共7页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China (Nos.21204055,21344002,21174098 and 21304062) and the Natural Science Foundation of Jiangsu Province (Nos.13KJA430006 and 13KJB430020).

摘　　要：A novel biomaterial based on polyurethane (PU) was prepared through physical incorporation of lysine-containing copolymer to improve its hemocompatibility and surface recognition of plasminogen.The lysine-containing copolymer was synthesized via the copolymerization of 2-ethylhexyl methacrylate (EHMA),oligo (ethylene glycol)methyl ether methacrylate (OEGMA) and 6-tert-butoxycarbonyl amino-2-(2-methyl-acryloylamino)-hexanoic acid tert-butyl ester (Lys(P)MA),followed by the deprotection of COOH and ε-NH2 groups on lysine residues in the copolymer.The composition of the copolymer can be adjusted by varying the monomer feed ratio.The three components contribute to improving the compatibility with PU,resistance to nonspecific protein adsorption and specific binding of plasminogen,respectively.The binding capacity towards plasminogen increased with the lysine content in the copolymer.This approach illustrates a simple way for the generation of novel biomaterials with improved hemocompatibility and surface recognition of specific biomolecules.A novel biomaterial based on polyurethane (PU) was prepared through physical incorporation of lysine-containing copolymer to improve its hemocompatibility and surface recognition of plasminogen.The lysine-containing copolymer was synthesized via the copolymerization of 2-ethylhexyl methacrylate (EHMA),oligo (ethylene glycol)methyl ether methacrylate (OEGMA) and 6-tert-butoxycarbonyl amino-2-(2-methyl-acryloylamino)-hexanoic acid tert-butyl ester (Lys(P)MA),followed by the deprotection of COOH and ε-NH2 groups on lysine residues in the copolymer.The composition of the copolymer can be adjusted by varying the monomer feed ratio.The three components contribute to improving the compatibility with PU,resistance to nonspecific protein adsorption and specific binding of plasminogen,respectively.The binding capacity towards plasminogen increased with the lysine content in the copolymer.This approach illustrates a simple way for the generation of novel biomaterials with improved hemocompatibility and surface recognition of specific biomolecules.

关 键 词：PLASMINOGEN protein adsorption hemocompatibility BLENDING LYSINE 

分 类 号：O6[理学—化学]