结晶样视网膜变性患者脉络膜和视网膜血流的异常变化  

Anomalies of choroidal and retinal blood flow in crystalline retinal degeneration

作　　者：何婷[1] 李孟达[1] 殷晓贝[1] 孙晓伟[1] 崔卉[1] 杨文利[1] 李根林[1] 

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室,北京市100730

出　　处：《眼科新进展》2014年第6期542-545,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81271046)~~

摘　　要：目的研究结晶样视网膜变性(crystalline retinal degeneration,CRD)患者眼动脉(OA)、视网膜中央动脉(CRA)和睫状后动脉(PCA)血流参数变化特点。方法应用彩色多普勒血流成像技术检测35例(35眼)临床诊断为CRD的患者。测定OA、CRA及PCA的收缩期峰速(PSV)、舒张末期流速(EDV)、时间平均最大流速(TAMV)、脉动指数(PI)和阻力指数(RI)。所得定量数据采用单样本t检验,对CRD组与正常组的各项参数进行比较。结果 CRD患者中OA的PI(1.80±0.55)较正常组(2.02±0.71)明显降低(t=-2.460,P=0.019)。CRD患者CRA的PSV(6.73±1.77)cm·s-1较正常组(10.82±2.97)cm·s-1明显降低(t=-13.649,P=0.000),EDV(2.10±0.41)cm·s-1较正常组(3.28±1.11)cm·s-1明显降低(t=-17.009,P=0.000),TAMV(3.60±1.00)cm·s-1较正常组(5.50±2.06)cm·s-1明显降低(t=-11.365,P=0.000),PI(0.67±0.09)较正常组(1.48±0.49)明显降低(t=-5.030,P=0.000)和RI(0.67±0.09)较正常组(0.71±0.08)明显降低(t=-2.774,P=0.009)。CRD患者PCA的PSV(6.64±1.76)cm·s-1较正常组(11.61±3.41)cm·s-1明显降低(t=-16.897,P=0.000),EDV(2.37±0.69)cm·s-1较正常组(3.34±1.25)cm·s-1明显降低(t=-8.327,P=0.000),TAMV(3.60±1.16)cm·s-1较正常组(5.83±1.91)cm·s-1明显降低(t=-11.374,P=0.000),PI(1.18±0.32)较正常组(1.49±0.43)明显降低(t=-5.690,P=0.000)和RI(0.64±0.82)较正常组(0.70±0.09)明显降低(t=-4.650,P=0.000)。结论 CRD患者OA、CRA和PCA血流参数异常提示眼部的血液供应和CRD病理过程存在相关性。Objective To study the changes of blood flow of ophthalmic artery （OA）, central retinal artery （CRA）and posterior ciliary artery （PCA）in patients with crystalline retinal degeneration （CRD）. Methods Color doppler flow imaging was used in 35 cases（35 eyes）of CRD patient to measure the peak systolic velocity（ PSV）, end diastolic velocity （ EDV ）, timeaveraged maximum velocity （ TAMV）, pulsatility index （PI） and resistance index （RI）in OA, CRA and PCA, respectively. Data was analyzed statistically by one-sample t test to compare changes of these parameters between CRD and normal group. Results Concerning CRD group, in OA, PI （ 1. 80 ±0.55 ） was significantly lower than normal（2.02 ±0.71 ） （ t = -2.460,P =0. 019） ;In CRA,PSA（6.73 ±1.77）cm · s^-1 was significantly lower than normal（10. 82 ± 2. 97）cm · s^-1（t = - 13. 649,P = 0. 000 ）, EDV （ 2.10 ±0.41 ）cm · s^-1 was signifieantly lower than normal （3.28 ±1. 11）cm· s^-1（t = -13. 649,P =0. 000）,TAMV（3.60 ±1.00）cm · s^-1 was sig- nifieantly lower than normal（ 5.50 ±2.06） cm · s^-1 （ t = - 11. 365,P = 0.000）, PI （ 0.67 ± 0. 09） was signifieantly lower than normal（ 1.48 ±0.49 ） （ t = - 5. 030 ,P = 0.000）, and RI （0.67 ±0. 09 ） was signifieantly lower than normal （ 0. 71 ±0.08 ） （ t = - 2. 774, P = 0. 009 ） ;In PCA, PSA（ 6.64 ±1.76 ）cm · s^-1 was significantly lower than normal（ 11.61 ±3.41 ） cm · s^-1 （ t = - 16. 897, P = 0. 000 ）, EDV （ 2.37 ±0.69 ） cm · s^-1 was signifieantly lower than normal（ 3.34 ±1.25 ） cm · s^-1 （ t = - 8. 327,P = 0. 000 ）, TAMV （ 3.60 ±1.16 ） cm· s^-1 was significantly lower than normal（5.83 ±1.91 ） cm · s^-1（ t = - 11. 374,P = 0. 000）, PI（ 1.18 ±0.32） was signifieantly lower than normal（ 1.49 ±0.43 ） （ t = - 5. 690, P = 0. 000 ）, and RI （ 0.64 ±0. 82 ） was significantly lower than normal （ 0.70 ±0. 09 ） （ t = - 4. 650,P = 0. 000）. Conclusion Hemo

关 键 词：结晶样视网膜变性 彩色多普勒血流显像 眼底血流灌注 

分 类 号：R774.130.4[医药卫生—眼科]