星点设计-效应面法优化姬松茸多糖分散片的处方  

Formulation optimization of Agaricus blazei polysaccharide immediate release tablets by central composite design-response surface methodology

作　　者：张彦青[1,2] 乔龙东 张婷[1] 叶媛媛[1] 张明春[1,2] 解军波[1,2] 

机构地区：[1]天津商业大学生物技术与食品科学学院,天津300134 [2]天津市食品生物技术重点实验室,天津300134

出　　处：《食品工业科技》2014年第13期240-243,共4页Science and Technology of Food Industry

基　　金：天津市科技支撑计划重点项目(12ZCZDNC01400);国家星火重点项目(2012GA610002)

摘　　要：采用湿法制粒压片法制备姬松茸多糖分散片,并应用星点设计-效应面法优化其处方。以姬松茸多糖、交联羧甲基纤维素钠和羟丙纤维素的用量为自变量,以崩解时间为优化指标,对实验数据进行多元线性模型和二次多项式模型拟合,结果表明二次多项式模型相关系数优于多元线性模型,为最终拟合模型。优化的姬松茸多糖分散片(片重200mg)的处方为:多糖提取物27.54%,交联羧甲基纤维素钠7.79%,羟丙纤维素4.17%,微晶纤维素59.5%,滑石粉1%。按照优化处方工艺条件制备3批姬松茸多糖分散片,检查结果均符合要求,说明该处方工艺具有良好的可行性。Agaricus blazei polysaccharide immediate release tablets were prepared through wet granulation andcompression methods. Central composite design-response surface methodology was applied to optimize theformulation with the amount of Agaricus blazei polysaccharide, croscarmellose sodium and hydroxypropylcelluloseas independent variables ,while disintegrating time was the evaluated index.The experimental data were analyzedto fit multivariate linear equation and second-order polynomial equation.Quadratic multinomial models were betterthan multivariate linear models. The optimum formulation （200mg tablet weight） was obtained as 27.54%polysaccharide,7.79% croscarmellose sodium,4.17% hydroxypropylcellulose,59.5% microcrystalline cellulose and1% talcum powder.According to the formulation,3 batches of Agaricus blazei polysaccharide immediate releasetablets were prepared successfully with perfect quality, indicating the optimized formulation was reasonable forpreparation of the tablets.

关 键 词：姬松茸多糖 分散片 星点设计-效应面优化法 处方 

分 类 号：TS202.3[轻工技术与工程—食品科学]