A Lipidomic Perspective on Intermediates in Cholesterol Synthesis as Indicators of Disease Status  

作　　者：Laura J.Sharpe Vicky Burns Andrew J.Brown 

机构地区：[1]School of Biotechnology and Biomolecular Sciences, The University of New South Wales

出　　处：《Journal of Genetics and Genomics》2014年第5期275-282,共8页遗传学报（英文版）

基　　金：support of the Tatu Miettinen Memorial Fund during the writing of this review

摘　　要：Lipidomics is increasingly becoming a viable method for researchers to routinely identify the various sterols present in samples, beyond just measuring cholesterol itself. In particular, the measurement of intermediates in cholesterol synthesis can shed new insights into not only the flux through the pathway, but also numerous disease states where levels of sterol intermediates are drastically altered. In this review, we indicate several intermediates that are relevant to disease, and discuss the challenges for analysing them, including the need for standardised methodology or universal controls across the lipidomics field.Lipidomics is increasingly becoming a viable method for researchers to routinely identify the various sterols present in samples, beyond just measuring cholesterol itself. In particular, the measurement of intermediates in cholesterol synthesis can shed new insights into not only the flux through the pathway, but also numerous disease states where levels of sterol intermediates are drastically altered. In this review, we indicate several intermediates that are relevant to disease, and discuss the challenges for analysing them, including the need for standardised methodology or universal controls across the lipidomics field.

关 键 词：CHOLESTEROL INTERMEDIATES LIPIDOMICS 

分 类 号：Q54[生物学—生物化学]