Bioinformatics Analysis Raises Candidate Genes in Blood for Early Screening of Parkinson's Disease  

作　　者：ZHANG Yi YAO Li LIU Wei LI Wei TIAN Chan WANG Zhao Yang LIU Di 

机构地区：[1]Cell Engineering Research Center, State Key Laboratory of Cancer Biology, Fourth Military Medical University [2]Department of Pathology, Tangdu Hospital, Fourth Military Medical University [3]The School of Acupuncture and Tuina, Beijing University of Chinese Medicine [4]Network Information Center, Institute of Microbiology, Chinese Academy of Sciences [5]State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases [6]National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention

出　　处：《Biomedical and Environmental Sciences》2014年第6期462-465,共4页生物医学与环境科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(81101302,31270185);SKLID Development Grant(2014,SKLID201)

摘　　要：Parkinson＇s disease （PD） is a typical degenerative disease, which is characterized by the most obvious symptoms of movement dysfunction, including shaking, rigidity, slowness of movement and difficulty in walking and gait. This disease can not be clearly identified through laboratory tests at present, thus application of high-throughput technique in studying the expression profiles of PD helps to find the genetic markers for its early diagnosis. Studies on expression profiles of neurodegenerative diseases have revealed the novel genes and pathways involved in the progress of illness. In this study, the expression profiles of PD in blood were compared, showing that 181 differentially expressed genes （DEG） exhibit a similar expression trend both in patients and in normal controls.Parkinson＇s disease （PD） is a typical degenerative disease, which is characterized by the most obvious symptoms of movement dysfunction, including shaking, rigidity, slowness of movement and difficulty in walking and gait. This disease can not be clearly identified through laboratory tests at present, thus application of high-throughput technique in studying the expression profiles of PD helps to find the genetic markers for its early diagnosis. Studies on expression profiles of neurodegenerative diseases have revealed the novel genes and pathways involved in the progress of illness. In this study, the expression profiles of PD in blood were compared, showing that 181 differentially expressed genes （DEG） exhibit a similar expression trend both in patients and in normal controls.

关 键 词：GENE Bioinformatics Analysis Raises Candidate Genes in Blood for Early Screening of Parkinson’s Disease GFAP PD SLC BCAM 

分 类 号：R742.5[医药卫生—神经病学与精神病学]