35例亚急性重症肝炎的超微结构分析  

ULTRASTRUCTURAL CHANGES OF HEPATOCYTES IN SUBACUTE SEVERE HAEATITIS

作　　者：丁长囡[1] 朱家颖 储谦[1] 沈耕荣[2] 周霞秋[2] 

机构地区：[1]上海第二医科大学附属瑞金医院病理科 [2]上海第二医科大学附属瑞金医院重肝研究室

出　　处：《上海医学》1993年第1期14-16,F004,共4页Shanghai Medical Journal

摘　　要：本文分析了35例亚急性重症肝炎(简称亚重肝)的超微结构改变。其中病因有 HBV 32例(91.4%),NANB 1例(2.9%),HBV 合并 HDV1例(2.9%),未定2例。早期4例(11.4%),中期24例(68、6%),后期7例(20%)。电镜下见大片肝细胞坏死,为炎症细胞取代,残存及再生肝细胞均呈不同程度的变性,浆内出现灶性及融合性液化区,细胞器严重损害,尤以线粒体及内质网为甚,作者认为光镜和电镜结合观察,是研究亚重肝形态改变的重要手段。The ultrastructural changes in liver cells were analysed in 35 cases of subacute viral fulminant hepatitis.Among them,32 cases were HBV,one was NANB and the etiology of other two were uncertain.Only one case of HBV was accompanied by HDV.Apart from massive confluent necrosis,most of the hepatocytes showed swelling of the mitochondria with reduction in the density of mitochondrial matrix,and dilated or vesiculated endoplasmic reticulum with disaggregation of polyribosomes.These events began with a virushepatocyte interaction that involved primary damage to the cell membrane,cyte organelles,mostly reversible.

关 键 词：亚急性 重症 肝炎 超微结构 细胞器 

分 类 号：R575.1[医药卫生—消化系统]