大蒜提取液对ENNG和MNU致突变作用的抑制效应研究  

REPRESSIVE EFFECT OF THE EXTRACTION OF GARLIC TO THE MUTAGENICITY OF ENNG AND MNU

作　　者：赵景春[1] 鄂文[2] 刘叔平[2] 

机构地区：[1]北京教育学院生物系,北京100011 [2]北京医科大学,北京100083

出　　处：《北京教育学院学报》2000年第3期45-47,67,共4页Journal of Beijing Institute of Education

摘　　要：本研究应用Ames试验的方法 ,以ENNG、MNU两种直接致癌、致突变作用的亚硝酰胺为阳性诱变物 ,对大蒜提取液的抗TA10 0诱变性进行了研究。结果表明 ,大蒜提取液对ENNG、MNU的致突变性有明显的抑制作用。抑制率可高达 83% ,并有较好的剂量反应关系。提示人们 。In this study,we used the Ames test.Selecting ENNG and MNU as positive inductor,which are two kinds of nitrsoylamine and are mutafacint and carcinogenic,we discussed anti-TA 100 mutagenicity of the extraction of garlic. The result is that the extraction of garlic signally repressed mutagenicity of ENNG and MNU,and the repressive rates even reached 83%.There was a better dosage-effect relation.The conclusion is that garlic is an antagonist of mutation and can prevcnt tumor.

关 键 词：大蒜提取液 AMES试验 亚硝基化合物 致突变作用 抑制效应 抗癌作用 剂量 

分 类 号：R730.1[医药卫生—肿瘤] R73－34[医药卫生—临床医学]