精神分裂症与补体第四成份C4A及C4B基因缺陷关联性研究  

Investigation of complement C4A and C4B deficiency in schizophrenia.

作　　者：陈毅昌[1] 陈家强[1] 张良诚[1] 蔡教壁[1] 伍新尧[2] 

机构地区：[1]广东省佛山市第三人民医院,佛山528041 [2]中山医科大学法医系

出　　处：《中国神经精神疾病杂志》2001年第2期103-105,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的　探讨补体第四成份C4A、C4B基因缺陷与精神分裂症的相关性。方法　采用Amp RFLP(ampli ficationrestrictionfragmentlengthpolymorphism)方法 ,对 192例精神分裂症患者和 142例健康对照组样本补体第四成份C4A、C4B基因缺陷的相关性进行研究。结果　精神分裂症患者与补体第四成份C4A基因缺陷纯合子C4AQ0 /C4AQ0的发病率显著高于对照组 (χ2 =8.5 4,P <0 .0 1) ,关联强度RR值为 6 8。精神分裂症患者与补体第四成份C4B基因缺陷纯合子C4BQ0 /C4BQ0的发病率与对照组进行比较无显著差异性 (χ2 =0 .11,P >0 .0 5 ) ,关联强度RR值为 0 73。Objective To assess the association between the gene of complement C4A, C4B deficiency and schizophrenia. Methods 192 patients with schizophrenia and 142 healthy controls were tested with the amplification restriction fragment length polymorphism (Amp RFLP) technique.Results The frequency of C4AQ0/C4AQ0 homozygote was higher in the patient group than in the control group ( χ 2=8.54, P<0.01 ). The relative risk (RR) of C4AQ0/C4AQ0 homozygote for schizophrenia was 6 8. There was no increased frequency of C4B deficiency in patients with schizophrenia ( χ 2=0.11, P>0.05, RR=0.73 ).Conclusions These results indicate that there is a positive association between complement C4A dificiency and schizophrenia. Moreover, our study did not support a widespread association between a deficiency in complement component C4B and schizophrenia.

关 键 词：精神分裂症 相关性研究 补体缺陷 6号染色体 

分 类 号：R749.3[医药卫生—神经病学与精神病学]