薄束轴索变性小鼠轴索内淀粉样β蛋白蓄积的研究  

Amyloid-β protein deposition in area of axon degeneration in Goll’s column of mouse

作　　者：吴江[1] 刘亢丁[1] 饶明俐[1] 

机构地区：[1]吉林大学第一医院神经内科,长春130021

出　　处：《中华神经科杂志》2001年第2期96-97,共2页Chinese Journal of Neurology

摘　　要：目的　探索薄束轴索变性 (GAD)小鼠薄束路系统的轴索变性和Aβ沉积的相互关系。方法　用免疫组织化学染色和HE染色镜像切片对照方法。结果　在GAD小鼠薄束路系统的轴索变性部位 ,有呈Aβ强阳性的类圆形沉积物。在 4周龄时 ,延髓的薄束核区已出现球状沉积物 (sphroid) ,但Aβ染色呈阴性。 9周龄时 ,该区的部分sphroid ,呈Aβ染色强阳性的类圆形沉积物。伴随着加龄更为明显 ,并与轴索进行性变性进展顺序一致地出现。结论　Aβ沉积与轴索变性密切相关 ,是神经轴索变性后继发产生的结果。Objective To investigate the relationship between axon degeneration of Goll’s column system and Amyloid β protein (Aβ) deposit sludge. Methods Aβ protein deposition in area of axon degeneration of Goll’s columns was measured by using immunohistochemical method.Results There was found strong positive round like Aβ deposit in the area of axon degeneration of Goll’s column system of GAD mouse. Spheroid appeared in the area of medullar nucleus of the Goll's column system at an age of 4 weeks. However the Aβ was negative and 9 weeks later, it became positive in partial spheroid and formed a strong round like material and became more and more standing up with age increase. The material mentioned above appeared consistently progressive in degeneration of axon in sequence.Conclusion It was suggested that the deposition of Aβ should be the result secondary to degeneration of nervous axon and be closely correlated with axon degeneration.

关 键 词：淀粉样Β蛋白 神经变性 球状细胞 延髓 老年性痴呆 

分 类 号：R749.16[医药卫生—神经病学与精神病学]