(E)-4-酰氧基苯基丙烯酸类衍生物的合成及抑癌活性  

Synthesis and Anticancer Activity of (E)-4- Acyloxypropenoic Acid Derivatives

作　　者：刘鹰翔[1] 计志忠[2] 牟孝硕[2] 张宝凤[2] 

机构地区：[1]广东药学院药学系,广东广州510224 [2]沈阳药科大学,辽宁沈阳110015

出　　处：《中国药物化学杂志》2001年第2期76-79,共4页Chinese Journal of Medicinal Chemistry

摘　　要：报道了 1 8个 (E) 4 酰氧基苯基丙烯酸类衍生物的设计与合成。其中 1 7个化合物未见文献报道。所有目标物的化学结构经元素分析、红外光谱和核磁共振氢谱确证。初步体外抑癌试验结果表明 ,化合物 3e、3f、3g、3h、3k、4h和 4 j在 0 3μmol·L-1浓度下对小鼠艾氏腹水癌 (EAC)In the paper the design and synthesis of eighteen compounds of( E ) 3 substituted 4 aryloxyphenylpropenoic acid were reported.Among them seventeen final target compounds had never been reported.The chemical structures of all the target compounds were determined by elementary analysis and IR as well as 1H NMR,etc.Preliminary results of anticancer tests in vitro showed that the test compounds 3e,3f,3g,3h,3k,4h and 4j had significantly anticancer activities on Ehrlich ascites carcinoma at 0 3 mmol·L -1 concentration.

关 键 词：(E)-酰氧基苯基丙烯酸 Doebner反应 抑癌活性 

分 类 号：R914[医药卫生—药物化学]