超选脑动脉灌注VM26并静滴BCNU治疗恶性脑瘤的疗效分析  

Therapeutic effects of superselective intracranial arterial infusion of VM26 in combination with intravenous dropping of BCNU on brain malignant tumor

作　　者：周政[1] 张可成[1] 钟建光[1] 杨辉[1] 

机构地区：[1]第三军医大学附属新桥医院神经外科

出　　处：《第三军医大学学报》1998年第1期53-55,共3页Journal of Third Military Medical University

摘　　要：目的：观察ＶＭ２６并ＢＣＮＵ静滴治疗恶性脑瘤的临床疗效。方法：对５６例脑瘤于手术切除后，采用超选脑动脉灌注ＶＭ２６并静滴ＢＣＮＵ，在治疗前后分别比较肿瘤体积变化及临床症状。结果：化疗前肿瘤平均体积为１５．１±７．３３ｃｍ３，化疗后平均体积为８．１１±８．９２ｃｍ３（Ｐ＜０．０１），总的有效率为６７．８％（３８／５６），完全缓解率为２１．４％（１２／５６）。本组病例１年存活率达７３．２％，２年存活率为４１．１％，全部患者均无眼部症状及严重的药物神经毒性反应。结论：超选脑动脉灌注和静滴联合化疗法，较单纯颈内动脉灌注及外周静脉化疗存活率高，而且并发症少，全身反应轻。Objective: To investigate the therapeutic effects of superselective intracranial arterial infusion of VM26 in combination with intravenous dropping of BCNU on brain malignant tumor. Methods: After the excision of brain malignant tumor, 57 patients were treated with superselective intracranial arterial infusion of VM26 in combination with intravenous dropping of BCNU. Then the changes of the size and clinical symptoms of the tumor after the chemotherapy were observed. Results: The average size of the tumor was significantly smaller after the chemotherapy (8.17±8.80 cm3) than before it (14.6±7.63 cm3, P<0.01). The total effective rate was 66.7% and the complete remissive rate 21.1%. The oneyear survival rate was 73.2% and the twoyear one 41.1%. None of the patients were found to exhibit vision decrease and serious neural intoxication. Conclusion: The superselective intracranial arterial infusion of VM26 in combination with intravenous dropping of BCNU is better than carotid internal arterial infusion or intravenous chemotherapy alone in treating the brain malignant tumor.

关 键 词：脑动脉 化学疗法 脑肿瘤 VM26 灌注治疗 静脉滴注 BCNU 

分 类 号：R739.41[医药卫生—肿瘤] R730.53[医药卫生—临床医学]