精神发育迟滞者与染色体脆性部位相关性的研究  

The study on correlativity between mental retardation and chromosome fragile site

作　　者：高文和[1] 

机构地区：[1]天津医科大学基础医学院生物学教研室,300070

出　　处：《天津医科大学学报》2001年第1期16-17,共2页Journal of Tianjin Medical University

摘　　要：目的 :探讨精神发育迟滞者与染色体畸变率和脆性部位表达率的相关性。方法 :采用外周血淋巴细胞染色体制备和脆性技术 ,对30例精神发育迟滞者和30例正常人的染色体畸变率和脆性部位表达率进行分析。结果 :精神发育迟滞者染色体的畸变率为4 32 % ,脆性部位的表达率为2 18% ,而正常对照组染色体畸变率为1 55 % ,脆性部位的表达率为0 89 % ,两者的染色体畸变率和脆性部位表达率有明显的差异 (P<0.01)。结论 :提示精神发育迟滞与染色体的畸变率和脆性部位的表达率有一定的相关性。Objective:To explore the correlatitiy between mental retardation,chromosome aberrtion rate and fragile site expression rate. Methods: Using the peripheral blood lymphocyte chromosome preparation technique and fragile site technique,to analyze chromosome aberrtion rate and fragile site expression rate of 30 cases of mental retardation sufferer and 30 cases of normal person respectively.Results: About the mental retardation sufferer,the chromosome aberration rate is 4.32%;the fragile site expression rate is 2.18%.About the control group,the chromosome aberration rate of is 1.55%;the fragile site expression rate is 0.89%.Both the chromosome aberration rate and the fragile site expression rate of two groups are distinct from each other(P<0.01). Conclusion: The mental retardation is correlative with the chromosome aberration and the fragile site expression rate.

关 键 词：精神发育迟滞 染色体畸变 染色体脆性部位 相关性 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]