Induction　of　Rat　Prolactinoma　by　β－Estradiol　and　Its　Relation　to　Expression　of　c－myc　Oncogene  

作　　者：许荣琨 郭传海 黄曼影 韩小四 周远征 单惠敏 黄醒亚 

出　　处：《Developmental and Reproductive Biology》1995年第1期64-69,T001-T002,共8页发育与生殖生物学报（英文版）

摘　　要：Sprague-Dawley rats were implanted with silastic capsules containing β-estradiol. After 60 days, their pituitary weights, serum prolactin contentsand transcription level of c-myc proto-oncogene were found increasedsignificantly. It was also found that the anterior pituitary cells proliferatedsignificantly, but their differentiation was suppressed.ＩｎｄｕｃｔｉｏｎｏｆＲａｔＰｒｏｌａｃｔｉｎｏｍａｂｙβ－ＥｓｔｒａｄｉｏｌａｎｄＩｔｓＲｅｌａｔｉｏｎｔｏＥｘｐｒｅｓｓｉｏｎｏｆｃ－ｍｙｃＯｎｃｏｇｅｎｅ￥ＸＵＲｏｎｇ－ｋｕｎ（许荣琨）；ＧＵＯＣｈｕａｎ－ｈａｉ（郭传海）；ＨＵＡＮＧＭａｎ－ｙ...

关 键 词：ESTRADIOL Anterior pituitary tumor PROLACTIN PROTOONCOGENE 

分 类 号：R736.4[医药卫生—肿瘤]