食管癌高低发区正常食管粘膜微量元素变化及扫描电镜观察  

Change of trace elements and observation of scanning electron microscope in the esophageal mucosae of normal people in high and low risk areas of esophageal cancer

作　　者：高新平[1] 赵卫星[1] 赵光明[1] 任金平[1] 张合喜[2] 张晓军 朱命炜[4] 

机构地区：[1]新乡医学院病理学教研室,,河南新乡453003 [2]预防医学教研室,河南林州456550 [3]林州市人民医院,,河南新乡453002 [4]河南师范大学生物系电镜室,

出　　处：《新乡医学院学报》2001年第2期91-93,96,共4页Journal of Xinxiang Medical University

基　　金：河南省卫生厅科研基金资助项目

摘　　要：目的　探讨食管癌高、低发区“正常”人群食管粘膜内微量元素变化与形态学之间关系。方法　X -射线能谱仪扫描电镜分别对高、低发区“正常”人群食管粘膜行微量元素检测及观察。结果　随年龄增长 ,食管粘膜微量元素Zn、Se、Mo含量呈递减趋势 ,Cu、Ni、Ca、Cu/Zn变化则呈递增趋势。高发区各组间Zn、Se、Mo差异显著 (p <0 .0 5 ) ,Cu、Ni、Ca除 2 5岁以上组与 35岁以上组外 ,余各组间差异显著 (p <0 .0 5 )。低发区Se各组间差异显著 (p <0 .0 5 ) ,Zn、Mo除 35与 45岁组外 ,Cu除 2 5与 35岁组外 ,余各组间有差异 (p <0 .0 5 )。形态学显示高发区食管炎和非典型增生发病率明显高于低发区 ,尤以中老年为著。结论　食管癌高发区中、老年食管粘膜内存在多种微量元素失衡 ,可能与食管癌前病变有关。Objective To investigate changes of trace elements and the relationship between the changes and morphologic results in the esophageal mucosae of normal people in high and low risk areas of esophageal cancer .Methods Using x-ray energy-dispersive-spectrometer and scanning electron microscopy, the quantities of the trace elements were determined and the pathologic histology was observed in normal people from high and low risk areas . Result The alter trend of Zn,Se and Mo in the esophageal mucosae was decreased and the Cu,Ni,Ca and Cu/Zn rate was increased with age growing.The Zn,Se and Mo was obvious difference in low risk areas(p<0.05).The Cu,Ni and Ca was obvious difference(p<0.05) except for 25 and 35 aged group in the high risk areas.In the low risk areas, however,the Se was obvious difference in the various group(p<0.05),Zn and Mo was obvious difference except for 35 and 45 aged group, Cu was obvious difference groups except between 25 and 35 aged group.Morphologic observation shown that the incidence of chronic inflammation and atypical hyperplasia of esophagus was much higher in the high risk areas than in the low, especially in the middle-aged and the senile. Conclusion The disturbance of the trace elements in the esophageal mucosae among the middle-aged and senile may correlate with the precancerosis of esophagus in the high risk areas.

关 键 词：食管癌 癌前病变 微量元素 X-射线能谱仪 扫描电镜 

分 类 号：R735.1[医药卫生—肿瘤]