生物检材中毒鼠强的GC-MS选择离子分析  

ANALYSIS OF TETRAMINE IN THE BIOLOGICAL SAMPLES BY GC - MS

作　　者：曹艳平[1] 卫煜英[1] 

机构地区：[1]山东省卫生防疫站,济南250014

出　　处：《化学分析计量》2001年第3期18-19,共2页Chemical Analysis And Meterage

摘　　要：采用二氯甲烷萃取GC-MS及选择离子定性的方法,检测了血液、尸体脏器中的灭鼠药毒鼠强(四次甲基二砜四胺)。毒鼠强分子量为240,其质谱图中有明显的分子离子峰240m/z、基峰42 m/z及212、185、132、121、92、76m/z的碎片离子峰。对212、240 m/z碎片离子进行扫描,可提高检测灵敏度。本法适用于中毒者血液和脏器中低含量毒鼠强的定性检测。Tetramine was extracted with dichloromethane from biological samples, such as blood of patients and internal organs of dead body, and analysed by GC - MS. Tetramine is a strong pestcide to rats and its chemical name is tetramethylenedisulfotetraamine. Its relative molecular weight is 240. Its mass spectra has obvious peak of M + 240 m/z, base fragment is 42 m/z. Other fragments are 212,185,132, 121,92,76 m/z, respectively. 212,240 m/z were selected in SIM. The sensitivity was improved, especially when the content of tetramine was lower.

关 键 词：生物检材 毒鼠强 中毒 选择离子 气相色谱-质谱 分析 

分 类 号：R991[医药卫生—毒理学] D919.4[医药卫生—药学]