胃癌患者血清CD_(44)、CD_(54)含量测定及临床意义研究  

Clinical Significance of Detection of CD44 and CD54 in Patients with Gastric Carcinoma

作　　者：陈卫昌[1] 严辉[1] 张学光[2] 蔡衍郎[1] 

机构地区：[1]苏州医学院附属第一医院消化内科,215006 [2]苏州医学院重点实验室

出　　处：《胃肠病学》2001年第2期87-98,共12页Chinese Journal of Gastroenterology

摘　　要：目的：探讨血清ＣＤ４４、ＣＤ５４含量变化与胃癌诊断及浸润、转移、预后等生物学行为的关系。方法：应用酶联免疫吸附测定（ＥＬＩＳＡ）方法检测２６例胃癌、１０例胃溃疡患者和２０例健康成人（正常对照组）的血清ＣＤ４４、ＣＤ５４含量，其中１０例胃癌患者在术后１个月复查ＣＤ４４、ＣＤ５４。结果：胃癌患者的血清ＣＤ４４、ＣＤ５４含量明显高于胃溃疡患者及正常对照组（Ｐ＜０．０５），但胃溃疡患者与正常对照组的含量无明显差异。血清ＣＤ４４、ＣＤ５４含量在直径＞５ｃｍ、侵及浆膜、伴淋巴结转移的肿瘤及Ⅲ、Ⅳ期肿瘤明显高于直径≤５ｃｍ、未侵及浆膜、无淋巴结转移的肿瘤及Ⅰ、Ⅱ期肿瘤（Ｐ＜０．０５），但与组织学类型无关。１０例复查胃癌患者中，８例术后血清ＣＤ４４、ＣＤ５４含量较术前明显下降（Ｐ＜０．０５），１例无明显下降，１例反而上升，这２例均与胃癌转移有关。结论：血清ＣＤ４４、ＣＤ５４含量测定有助于胃癌的早期诊断和预测术后复发，是一项评价疗效和预后的客观指标。Background/Aims: To explore the changes of serum CD44 and CD54 as well as the relations to the diagnosis and biological behaviors such as invasion, metastasis and prognostic evaluation in patients with gastric carcinoma. Methods: CD44 and CD54 were measured by enzyme-linked immunosorbent assay (ELISA) in 26 cases of gastric carcinoma, 10 gastric ulcer and 20 healthy adults served as controls. 10 gastric carcinoma patients were reexamined one month after operation. Results: Serum CD44 and CD54 were higher in patients with gastric carcinoma than those in gastric ulcer and the controls (P< 0.05), but no difference was found between gastric ulcer group and the controls. Serum CD44 and CD54 in tumor diameter ＞5cm, T３, T４, N１, N２ and Ⅲm, Ⅳ stages were higher as comparing with those with diameter ≤5cm, T1, T2, N0, and Ⅰ, Ⅱ stages (P<0.05), but there were no differences with regard to histological types. In ten reexamined cases, there was no significant decrease of CD44 and CD54 in one case, but increase in another case, which was probably related to the metastasis of gastric carcinoma. In the remaining eight cases, CD44 and CD54 were lower than prior to operation (P< 0.05). Conclusions: The measurement of serum CD44 and CD54 is useful for early diagnosis and prediction of recurrence after operation, and it may provide an objective marker for assessing the therapeutic effect and predicting the prognosis of gastric carcinoma.

关 键 词：胃肿瘤 抗原 CD44 细胞间粘附分子1 CD54 

分 类 号：R735.2[医药卫生—肿瘤]