原发性鼻咽癌中高频率的4q增多和1p丢失  

Frequent chromosomal gain of 4q and loss of 1p in primary nasopharyngeal carcinoma

作　　者：鄢践[1] 方嬿[1] 梁启万[1] 黄贻学[1] 李辉梅[1] 曾益新[1] 

机构地区：[1]中山医科大学肿瘤防治中心肿瘤研究所,广州510060

出　　处：《中华肿瘤杂志》2001年第3期208-210,共3页Chinese Journal of Oncology

基　　金：国家973项目基金资助(G1998051202);国家杰出青年科学基金B类资助(39825511)

摘　　要：目的　阐明中国广东籍患者原发性鼻咽癌 (NPC)的遗传学变化。方法　用比较基因组杂交技术 (CGH)检测 17例原发性NPC遗传物质的增多和丢失情况。结果　在半数以上患者中发现4q增多和 1p丢失。其他较为常见的染色体变化是 12q、1q、2q、3q和 8q增多 ,以及 3p、11q、14q、15q、13q、Xq、9q、10p、10q和 16q丢失。结论　广东原发性NPC的遗传学改变为 4q、12q和 1q增多以及 1p、3p、11q和 14q丢失 ,这些区域可能含有与NPC发病有关的癌基因与抑癌基因。Objective To reveal the genetic changes of nasopharyngeal carcinoma (NPC) in Cantonese.Methods Comparative genomic hybridization (CGH) was performed on 17 primary NPC biopsy specimens to find out any gain or loss of genetic material. Results A novel copy number gain on chromosome 4q and loss of chromosome 1p were found at high frequency (>50%). The other more common genetic alteratons included gain of chromosomes 4q, 12q, and 1q as well as loss of chromosomes 1p, 3p, 11q, 14q, 15q, 13q, Xq, 9q, 10p, 10q, and 16q. Conclusion Current analysis has revealed a comprehensive profile of the chromosomal changes in NPC. Frequently altered loci may encode oncogenes or tumor suppressor genes involved in the development of primary NPC.

关 键 词：鼻咽肿瘤/遗传学 比较基因组杂交 染色体畸变 

分 类 号：R739.6[医药卫生—肿瘤]