基于外部基准框架的SPECT与MRI/CT的刚性配准及融合  

Rigid Registration and Fusion between SPECT and MRI/CT Based on External Fiducial Alignment

作　　者：李世星[1] 管梁[2] 庄天戈[1] 朱承谟[2] 吕中伟[2] 

机构地区：[1]上海交通大学生物医学工程系,上海200030 [2]上海第二医科大学附属瑞金医院,上海200025

出　　处：《中国医疗器械杂志》2001年第4期192-195,共4页Chinese Journal of Medical Instrumentation

基　　金：国家自然科学基金 3 9770 2 3 6号

摘　　要：设计了一种简便、有效的基于外部基准框架的SPECT(单光子发射型计算机断层 )与MRI/CT的刚性配准及融合的方法。在对图像进行一值化分割的基础上 ,运用侵蚀、扩张等图像处理算法确定图像中用于配准的相应点的坐标 ,然后利用这些对应点最小化代价函数并获得一个最佳刚性变换 ,实现图像的精确配准及融合显示。通过对作为外部基准框架的N型支架的设计及成像过程中对其与病人相对位置的严格限制 ,最大程度地减少成像中的误差。A convenient an d effective method of rigid registration and fusion between SPECT and MRI/CT which is based on external fiducial alignment system is designed. After thresholding the image, m any image processing arithmetics such as erasion, dilation are used to ensure th e corresponding points which will be used to registrate. Then these points are u sed to minimize the cost function. In this way, an optimal rigid transform is go tten to registrate the images accurately and fuse them well. Error in the regist ration and fusion is reduced furthest by well designing the N-shape bracket whi ch is used as the extemal fiducial alignment system and also by limiting the rel ative displacement betweent the bracket and the patient. Experimentation shows t hat this method can realize the registration and fusion of SPECT and MRI/CT effe ctively.

关 键 词：刚性配准 图像融合 自动分割 外部基准框架 代价函数 SPECT MRI/CT 

分 类 号：R318.6[医药卫生—生物医学工程] R445[医药卫生—基础医学]