大黄鞣质对实验动物减体重生理机制的研究  

Studies on Physiological Mechanism of Rhubarb Tan to Weight Loss of Experimental Animal

作　　者：孙霞[1] 梁国庆[1] 李继承[2] 吴培林[1] 

机构地区：[1]浙江省杭州医学高等专科学校,杭州310002 [2]浙江大学

出　　处：《浙江中医学院学报》2001年第4期47-49,共3页Journal of Zhejiang College of Traditional Chinese Medicine

摘　　要：目的 :研究大黄主要成分之一“大黄鞣质”在大黄减体重生理机制中的作用。方法 :胃饲去鞣质大黄水浸煎剂和腹腔、静脉给予没食子酸 (Gallic acid) ,观察对大鼠体重、摄食量、胃排空速度以及胰酶、肝胆汁分泌量的影响。结果 :去鞣质大黄可使肝胆汁分泌量增加 (P<0 .0 5 ) ,但对大鼠胰酶分泌量没有作用 (与对照组相比 P>0 .0 5 )。Gallic acid腹腔、静脉给药均引起大鼠胰酶分泌量降低 (与对照组相比 P<0 .0 1 ) ,但肝胆汁分泌量与对照组相比没有变化 (P>0 .0 5 )。结论 :减体重作用与胃的排空抑制。Objective:To investigate the physiologicalmechanism of weightloss of tan in Rhubarb.Method and Result:(1 ) Endogastric administration of tan-extracted Rhubarb had no effecton gastric emptying and pancreatic enzyme secretion,buthepatic-bile secretion was increased.(2 ) Both i.p.and i.v.administration of gallicacid inhibited pancreatic enzyme secretion.Conclusion: Tan in Rhubarb can inhabitgastricemptying and reducepancreaticenzyme secretion.Tan-extracted Rhubarb can increasehepatic bile secretion and has no effect on weight loss.The effect of weight loss is related to the inhabiting of gastric emptying and pancreatic enzyme secretion reducing and hepaticbile secretion increasing.

关 键 词：大黄 鞣质 没食子酸 胰酶 减体重 实验研究 

分 类 号：R282.71[医药卫生—中药学]