阿尔茨海默病患者红细胞超氧化物歧化酶与载脂蛋白ε_4等位基因的相互关系  

Relationship among apolipoprotein ε_4 allele and erythrocyte superoxide dismutase and clinical characters of sporadic probable Alzheimer′s disease

作　　者：张旭[1] 吴文源[1] 江三多[2] 崔海松[1] 万海英[3] 

机构地区：[1]同济大学附属同济医院心身科,上海200065 [2]上海市精神卫生研究所 [3]同济大学附属同济医院心身科检验科,上海200065

出　　处：《中华精神科杂志》2001年第3期146-149,共4页Chinese Journal of Psychiatry

基　　金：铁道部专项基金资助项目 (J97Z0 0 2 );同济大学附属同济医院科研基金资助项目 (GQ990 1);上海市医学领先专业老年精神医学重点学科建设基金资助项目 ( 95 Ⅲ 0 11)

摘　　要：目的　探讨阿尔茨海默病 (AD)患者的外周血氧化应激与载脂蛋白 (apo)Eε4 等位基因的相互关系。方法　分别测定 2 5例散发性AD患者 (AD组 )、2 0例血管性痴呆 (VD)患者、2 2名正常人(正常组 )的红细胞超氧化物歧化酶 (SOD)、血浆一氧化氮 (NO)浓度及apoE等位基因频率。结果　AD组的SOD活性 [U /mg血红蛋白 ]为 10 80± 35 1,明显高于正常组 [(818± 330 )U],P <0 0 5 ;NO浓度的差异无显著性。根据apoEε4 等位基因进行分层后 ,不携带ε4 组间SOD活性差异有显著性 ,AD组高于正常组 (P <0 0 5 )。AD患者的SOD活性与临床痴呆分级量表 (CDR)呈显著性负相关 (r =- 0 480 ,P <0 0 5 ) ,与BLESSED痴呆量表分呈显著性负相关 (r =- 0 5 2 2 ,P <0 0 1) ,正常组的SOD活性与年龄呈显著性负相关 (r=- 0 430 ,P <0 0 5 )。结论　与痴呆严重程度有关的氧化应激可能参与AD患者的病理生理变化 ,并可能受ε4Objective To investigate the relationship among apolipoprotein ε 4 allele and oxidative stress markers in peripheral blood and clinical characters of patients with sporadic probable Alzheimer′s disease (AD) Methods Twenty five patients with AD, 20 with vascular dementia (VD) and 22 normal controls were recruited Cognitive function, daily life ability were evaeuated clinical data and venous blood samples were obtained Allele frequencies of apolipoprotein E, activity of superoxide dismutase (SOD) in erythrocytes homogenate and plasma nitric oxide (NO) levels, were measured Results Compared with normal control, the SOD activity was significantly higher in AD patients ( P <0 05), but NO activity was no difference ( P >0 05) Additionally, SOD activity was negatively correlated with the severity of dementia in AD ( P <0 05, but not in VD) Conclusion These findings suggest oxidative stress may be involved in pathophysiological variance of AD, and might be influenced by ε 4 allele

关 键 词：ALZHEIMER病 超氧化物歧化酶 载脂蛋白E类 等位基因 阿尔茨海默病 早老性痴呆 

分 类 号：R749.161[医药卫生—神经病学与精神病学]