核桃油和核桃油复合维生素E对大鼠血浆脂质的影响  

EFFECTS OF WALNUT OIL AND WALNUT OIL VITAMIN E COMPLEX ON PLASMA LIPID IN RATS

作　　者：杨栓平[1] 常学锋[2] 王志平[1] 李文德[3] 

机构地区：[1]山西医科大学药理教研室,太原030001 [2]吉林大学第一医院急救医学科 [3]山西大学谷物化学及品质鉴定实验室,太原030009

出　　处：《营养学报》2001年第3期267-270,共4页Acta Nutrimenta Sinica

基　　金：山西省留学人员基金;山西省自然科学基金 ( No.9910 99);山西省教委攻关基金 ( No.990 0 6 )

摘　　要：目的 :　观察不同剂量核桃油和核桃油加维生素 E(核桃油复合 VE)对大鼠血脂和动脉粥样硬化的作用。方法 :　 80只 Wistar大鼠 ,雌雄各半 ,用高脂饲料制作动物高脂血症和动脉粥样硬化模型 ,然后将动物分为 5组 ;核桃油低、高剂量组 ,0 .3g/kg bw、1 g/kg bw;核桃油复合VE(核桃油和 VE的比例为每 3g核桃油中含 0 .2 g VE)低、高剂量组 ,0 .3g/kg bw、1 g/kg bw;对照组以 1 ml/kg生理盐水灌胃 ,实验各组均每天灌胃油剂一次 ,连续 4w。结果 :　 1 .核桃油和核桃油复合 VE对大鼠摄食及生长发育均无影响。 2 .核桃油能明显降低的雄性高脂血症大鼠血中的总胆固醇 ( TC)、甘油三酯 ( TG)、升高载脂蛋白 AI( Apo- AI) ,明显降低雌性高脂血症大鼠血中的 TG水平 ,升高其 Apo- AI。 3.核桃油复合 VE能显著降低雄性高脂血症大鼠血中的 TC、低密度脂蛋白胆固醇 ( LDL- C) ,高剂量核桃油复合 VE还能升高其血浆高密度脂蛋白胆固醇 ( HDL- C)、提高动物的抗动脉粥样硬化指数 ( AAI) ;对雌性大鼠除与雄性大鼠有类似的作用之外 ,还能明显降低血中TG和 Apo- B水平。结论 :　核桃油和核桃油复合Objective: To demonstrate the effects of walnut oil and walnut oil VE complex on plasma lipid and atherosclerosis. Methods: 80 Wistar rats (half female and half male) were given high fat diet to induce the hyperlipidemia model. Then the animals were divided into 5 groups:walnut oil 1g/kg group, walnut oil 0.3g/kg group, walnut oil VE complex 1g/kg group, walnut oil VE complex 0.3g/kg group and control group. The oil was given by gavage one time a day for 4 w respectively. Results: 1.Both walnut oil and walnut oil VE complex didnt affect the growth and development of rats. 2.Walnut oil significantly lowered plasma TC,TG, and elevated Apo AI in male rats, significantly lowered TG,Apo B and elevated Apo AI in female rats. 3.Walnut oil VE complex significantly lowered plasma TC,LDL C, elevated HDL C and Apo AI in male rats; in female rats, in addition to the similar effects in male rats, walnut oil VE complex significantly lowered TG, Apo B, though no effect on HDL C. Conclusion: Both walnut oil and walnut oil VE complex have the protective effects on hyperlipidemia and atherosclerosis in rats.

关 键 词：核桃油 维生素E 血浆脂质 大鼠 

分 类 号：R151[医药卫生—营养与食品卫生学]