乳头状瘤病毒感染及郎格罕细胞抗癌作用与宫颈癌预后的关系  

Mutliple Variable Analyses of Influencing the Prognosis of Cervical Cancer

作　　者：陈亦乐[1] 吴晓英[2] 王静[1] 张淑安[2] 陈森林[1] 刘保安[1] 彭隆祥[2] 

机构地区：[1]湖南省肿瘤医院,中国湖南长沙410006 [2]中南大学医学院电镜室,中国湖南长沙410008

出　　处：《湖南医学》2001年第5期329-330,共2页Hunan Medical Journal

基　　金：湖南省卫生厅科研基金资助(编号95-67)

摘　　要：目的研究并比较多种因素对宫颈癌预后的影响。方法对 94例宫颈癌标本用免疫组化方法显示并计量郎格罕细胞 (LC)数 (X1) [1] ,用原位杂交法测出HPV感染状况并分级 (X2 ) [2 ] ,将上述二项指标与患者的年龄 (X5) ,临床分期 (X3) ,病理分级 (X4 ) ,治疗方式(X6)共 6项因素 ,对存活期 (Y)的影响进行多因素逐步回归分析。结果一般回归方程Y =177.344+1.6 6 8X1-18.799X2 -6 .46 0X3-2 1.988X4 ;标准回归方程Y= 0 .430X1-0 .2 5 1X2 -0 .2 0 6X3-0 .179X4 。结论①对宫颈癌预后有作用的主要因素有LC数 ,HPV感染 ,临床分期 ,病理分级 ;②LC对宫颈癌患者存活期影响最大呈正相关 ;HPV感染、临床分期。ObjectiveTo study and compare the effect of multiple factors(X 1～6 ) on the prognosis of cervical cancer.MethodUsing immunohistochemical staining to mark the langerhans cells and account the number of them (X 1).The rate of virus infection(X 2) was measured by in situ hybridization.Then with multiple step linear regression analyses,we study the effect of X 1,X 2,X 3(clincal stages),X 4(pathological grades),X 5(the age of patients) and X 6(therapy methods) on Y(survival time).ResultRegression equation:Y=177.344+1.668X 1 -18.799X -6.460X 3 -21.988X 4;Standardized regression equation:Y=0.430X 1-0.251X 2-0.206X 3-0.179X 4.ConclusionX 1,X 2,X 3,and X 4 are the main factors influencing the prognosis of cervical cancer.The number of Langhans cells(X 1) played the major positive role to the prognosis of cervical cancer,while the effect of X 2,X 3 and X 4 are negatively correlated.

关 键 词：乳头状瘤病毒感染 郎格罕细胞 微生物学 预后 宫颈癌 抗癌作用 

分 类 号：R737.33[医药卫生—肿瘤]