中期和晚期乳腺单纯癌癌细胞器形态参数的逐步判别分析  

Research the cells-apparatus morphologigal parameters of simple breast carcinoma by stepwise discriminant analysis in the middle and late stages

作　　者：李维波[1] 陈平[1] 刘美玉[1] 钱纬[2] 刘爱武[2] 张文莉[3] 

机构地区：[1]昆明医学院物理数学教研室,云南昆明650031 [2]昆明医学院电镜室,云南昆明650031 [3]云南省肿瘤医院,云南昆明650101

出　　处：《中国医学物理学杂志》2001年第4期229-230,共2页Chinese Journal of Medical Physics

基　　金：云南省教委应用基础研究基金资助(9512002)

摘　　要：用体视学方法测出20例中期和20例晚期乳腺单纯癌癌细胞及正常细胞线粒体、溶酶体的16个形态参数,再用逐步判别分析法剔选指标,建立判别函数。结果筛选出细胞器的形态参数为:线粒体的外膜面密度、内膜面密度、嵴膜比表面、面数密度以及溶酶体的单膜面密度。结果表明线粒体的外膜面密度等5个形态参数也许能作为区别不同期乳腺单纯癌的最佳指标。Stereologic method was applied in analyzing16morphological parameters of the mitochondrion,lysosome of20cases in the middle and20cases in late stage of the simple breast carcinoma and the normal cells,and then the discriminant function was established by stepwise discriminant analysis.They were sifted that the cell-apparatus morphological parameters:the surface density of mitochondria outer membrane,the surface density of mitochondria inner membrane,the specific surface of mitochondria cristae,the numerical density on area of mitochondrion,the surface density of single lysosome membrane.It was shown that5morphological parameters of the surface density of mitochondrion outer membrane were the best target for discriminant the simple breast carcinoma among their different stages.

关 键 词：乳腺单纯癌 细胞器 形态参数 体视学 逐步判别分析 

分 类 号：R737.902[医药卫生—肿瘤] R329.4[医药卫生—临床医学]