体外模拟高强度聚焦超声适形扫描离体牛肝设定靶区的实验研究  

Extracorporeal Simulating ablation on ox liver tissue with 3D scanning high-intensity focused ultrasound

作　　者：伍烽[1] 王芷龙[1] 陈文直[1] 白晋[1] 邹建中[1] 叶方伟[1] 陈迅[1] 朱辉[1] 齐家俊[1] 王智彪[1] 

机构地区：[1]重庆医科大学医学超声工程研究所,附属第二医院肿瘤中心重庆400010

出　　处：《实用肿瘤杂志》2001年第6期379-381,共3页Journal of Practical Oncology

基　　金：国家"九五"科技重点攻关项目 (96 -0 2 - 0 1);国家自然科学基金委员会项目 (39770 841)资助

摘　　要：目的　体外模拟高强度聚焦超声 (high- intensity focused ultrasound,HIFU )点组合扫描破坏三维立体靶区的过程 ,为 HIFU治疗肝肿瘤的临床方案提供实验依据。方法　在 B超实时监控下 ,采用从点到线 ,从线到面 ,由面到体的 HIFU立体组合扫描方式破坏离体牛肝组织内的设定靶区 ,测定凝固性坏死灶的大小、形状和体积。结果　 HIFU立体组合扫描方式能使牛肝组织内预先设定的任意大小、形状的靶区出现凝固性坏死 ,受损区与正常组织边界清楚。结论　 HIFU能沿设定靶区边界实时完全破坏三维立体的肝内靶区组织。Objective In order to provide data for clinical treatment of hepatocellular carcinoma with high-intensity focused ultrasound (HIFU), the study is to simulate the process of HIFU 3D scanning treatment to destroy targeted ox liver tissue extracorporeally. Methods With real-time monitor of diagnostic ultrasound scanner, HIFU 3D scanning treatment of targeted ox liver tissue in vitro was performed with the therapeutic plan from dot to line, line to slice, and slice to volume. Following the treatment, the size, shape, and volume of coagulative necrosis were measured. Results While guided by B-mode ultrasound scanner, HIFU 3D scanning ablation caused coaguative necrosis of pre-determined target region in any size and shape within the ox liver tissue. The border between damaged tissue and normal tissue was remarkably clear. Conclusion HIFU can cause destruction of liver tissne volume completely with a distinct border,which may be applied in clinical treatment of hepatic tumor.;

关 键 词：实验性肝肿瘤 超声波治疗 体外模拟 高强度聚焦超声适形扫描 HIFU 

分 类 号：R730.41[医药卫生—肿瘤]