遗传性非息肉病性结直肠癌家族多原发癌的特点  

Features of the multiple primary cancer in hereditary nonpolyposis colorectal cancer kindreds

作　　者：金黑鹰[1] 崔龙[1] 孟荣贵[1] 喻德洪[1] 阎于悌[2] 徐洪莲[1] 刘飞[3] 

机构地区：[1]第二军医大学附属长海医院肛肠外科,上海200433 [2]甘肃省人民医院肛肠科 [3]南京市中医院肛肠科

出　　处：《中华胃肠外科杂志》2001年第3期165-166,共2页Chinese Journal of Gastrointestinal Surgery

基　　金：国家自然科学基金资助项目(39970823)

摘　　要：Objective To study the clinicopathological fe atures of the multiple primary cance r in Chinese hereditary nonpolyposis colorectal cancer(HNPCC).Methods Thirty-two kindreds with HNPCC were registered and followed up.Clinical data were analyzed.Results Among 91cases of 32HNPCC kindreds,10cases from 9kindreds developed multiple metachronous prim ary cancers and no synchronous cancers were found.Eight cases of ab ove 10cases were from typical HNPCC f amilies.The initial cancer presented as colorectal cancer in 9p atients.The second tumor presented as colonic cancer in 3patients,hepatic cancer.oophoroma and endom etrial carcinoma in 2patients respectively,and cereglioma in one patient.The second tumor occurred a fter 60～108mouths(mean 68mouths).Conclusions The morbidity of the multiple primary cancer of Chi nese HNPCC kindreds increases.HNPC C patients should be followed up strictly in order to discover multip le primary cancer earlier and get better outcome.Objective To study the clinicopathological fe atures of the multiple primary cance r in Chinese hereditary nonpolyposis colorectal cancer(HNPCC).Methods Thirty-two kindreds with HNPCC were registered and followed up.Clinical data were analyzed.Results Among 91cases of 32HNPCC kindreds,10cases from 9kindreds developed multiple metachronous prim ary cancers and no synchronous cancers were found.Eight cases of ab ove 10cases were from typical HNPCC f amilies.The initial cancer presented as colorectal cancer in 9p atients.The second tumor presented as colonic cancer in 3patients,hepatic cancer.oophoroma and endom etrial carcinoma in 2patients respectively,and cereglioma in one patient.The second tumor occurred a fter 60～108mouths(mean 68mouths).Conclusions The morbidity of the multiple primary cancer of Chi nese HNPCC kindreds increases.HNPC C patients should be followed up strictly in order to discover multip le primary cancer earlier and get better outcome.

关 键 词：遗传性非息肉病性结直肠肿瘤 多原发肿瘤 HNPCC 分子遗传学 错配修复基因 

分 类 号：R735.34[医药卫生—肿瘤]