胃肠多重癌微卫星不稳定性的研究  

Microsatellite Instability in the Multiple Primary Gastric and Colorectal Cancer

作　　者：饶本强[1] 兰小鹏[2] 涂小煌[1] 王瑶[1] 郑智勇[3] 胡还章[1] 季天海[3] 

机构地区：[1]南京军区福州总医院肿瘤外科 [2]南京军区福州总医院实验科 [3]南京军区福州总医院病理科,350025

出　　处：《中国误诊学杂志》2001年第11期1604-1606,共3页Chinese Journal of Misdiagnostics

摘　　要：目的　探讨胃肠多重癌发生的分子诊断标志物。方法　用 PCR方法对 1 5例胃肠多重癌患者术后所得肿瘤进行微卫星不稳定性 ( MSI)的检测。结果　 1 5例胃肠多重癌中 ,9例胃癌 MSI阳性 ,阳性率为 6 0 .0 % ( 9/1 5) ;1 1例肠癌 MSI阳性 ,阳性率为 81 .2 % ( 1 1 /1 5)。而 1 5例单纯胃癌 MSI阳性表达率仅为 1 3.3% ( 2 /1 5) ,1 5例单纯肠癌 MSI阳性表达率为 2 0 .0 % ( 3/1 5)。多重癌与单纯癌相比有非常显著性差异 ( P<0 .0 0 1 )。结论　胃肠肿瘤 MSI的表达可以作为其多重癌发生的有用的分子诊断标志物 ,对 MSI表达阳性的胃肠肿瘤患者 ,应警惕多重癌发生的可能性。Objective To study the diagnostic marker of molecular in the multiple primary gastric and colorectal cancer(MPGCC).Methods Expression of microsatellite instability(MSI) in the MPGCC were studied by PCR methods.Results In 15 cases of MPGCC,9 of 15 cases (60%) gastric cancers were MSI positive,11 of 15 cases (81.2%) colorectal cancers MSI positive. While in 15 cases of solitary gastric or colorectal cancers, only 2 of 15 cases solitary gastric cancers(13.3%) were MSI positive, and 3 of 15 cases solitary colorectal cancers (20%) MSI positive,there was a significant differences between the MPGCC and the solitar gastric or colorectal cancers(P<0.001).Conclusions The microsatellite instability plays an important role in the development of MPGCC and may be a diagnostic marker of MPGCC.

关 键 词：胃肠肿瘤多重癌 微卫星不稳定性 分子诊断 MPGCC 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]